{"id":59759,"date":"2007-06-07T00:00:00","date_gmt":"2007-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-sesterterpenolidas-e-indol-diterpenos-thiersindol-c\/"},"modified":"2007-06-07T00:00:00","modified_gmt":"2007-06-07T00:00:00","slug":"sa%c2%adntesis-de-sesterterpenolidas-e-indol-diterpenos-thiersindol-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-sesterterpenolidas-e-indol-diterpenos-thiersindol-c\/","title":{"rendered":"S\u00edntesis de sesterterpenolidas e indol-diterpenos thiersindol c"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Angel Escola Garcia <\/strong><\/h2>\n<p>En el trabajo titulado \u00abs\u00edntesis de sesterterpenolidas e indol-diterpenos. Thiersindol c\u00bb, se describe la s\u00edntesis de una serie de sesterterpenolidas an\u00e1logas de disidiolida, de un indol-diterpeno, thiersindol c, as\u00ed como una aproximaci\u00f3n sint\u00e9tica a los is\u00f3meros estructurales de este \u00faltimo, thiersidol a y b. Tambi\u00e9n se han sintetizado compuestos de estructura hexahidrocarbaz\u00f3lica an\u00e1logos de tubingensin a y b, terpeno-carbazoles que poseen actividad antitumoral. Como material de partida se emplea \u00e1cido ent-hal\u00edmico (componente mayoritario de halimium viscosum, quimiotipo: villarino de los aires).   disidiolida es la sesterterpenolida natural que mayor inter\u00e9s ha suscitado en los \u00faltimos a\u00f1os debido a su actividad antitumoral. Para la s\u00edntesis de los distintos an\u00e1logos propuestos, desde \u00e1cido ent-hal\u00edmico, se utilizan estrategias sint\u00e9ticas an\u00e1logas entre s\u00ed, dirigidas a la elaboraci\u00f3n de una cadena norte insaturada y una cadena sur altamente funcionalizada que contiene la \u00c2\u00bf-hidroxibutenolida. Las sesterterpenolidas sintetizadas, que se obtienen en un n\u00famero reducido de pasos y con buenos rendimientos. Estos compuestos han mostrado elevada actividad antitumoral frente a diferentes l\u00edneas tumorales humanas.  las s\u00edntesis de (+)-thiersindol c ha permitido corroborar la estructura y establecer la configuraci\u00f3n absoluta propuesta para el producto natural, (-)-thiersindol c. Dicha s\u00edntesis, pese a que requiere un n\u00famero elevado de pasos, se realiza con un rendimiento global pr\u00f3ximo al 14%. Este indol-diterpeno tambi\u00e9n fue sometido a ensayos de actividad antitumoral mostrando una  inhibici\u00f3n de la proliferaci\u00f3n celular a nivel 10-5 m.  se ha conseguido realizar reacciones de ciclaci\u00f3n radicalaria de un fenilselenoester obteniendo un sistema tricarboc\u00edclico similar al que posee thiersindol a y b.  se han obtenido compuestos de estructura hexahidrocarbaz\u00f3lica, a partir de un indol-sesquiterpeno, de forma altamente estereoselectiva por reacci\u00f3n de ciclaci\u00f3n en medio \u00e1cido entre el sistema ind\u00f3lico y una olefina anular de la parte terp\u00e9nica. Estos alcaloides presentan actividad antitumoral moderada en el rango de 10-5 m.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de sesterterpenolidas e indol-diterpenos thiersindol c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de sesterterpenolidas e indol-diterpenos thiersindol c <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Angel Escola Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Sanchez Marcos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Gotor santamar\u00eda <\/li>\n<li>Andr\u00e9s Garcia granado lopez del hierro (vocal)<\/li>\n<li>Andr\u00e9s Parra sanchez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Miguel del corral santana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Angel Escola Garcia En el trabajo titulado \u00abs\u00edntesis de sesterterpenolidas e indol-diterpenos. Thiersindol c\u00bb, se describe [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[645,21525,416,9386],"tags":[1653,71862,39605,3428,132002,6659],"class_list":["post-59759","post","type-post","status-publish","format-standard","hentry","category-hidrocarburos-alifaticos","category-hidrocarburos-aromaticos","category-quimica-organica","category-salamanca","tag-andres-garcia-granado-lopez-del-hierro","tag-andres-parra-sanchez","tag-isidro-sanchez-marcos","tag-jose-maria-miguel-del-corral-santana","tag-miguel-angel-escola-garcia","tag-vicente-gotor-santamaria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59759"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59759\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}