{"id":59880,"date":"2007-12-07T00:00:00","date_gmt":"2007-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-traduccional-y-post-traduccional-de-una-proteina-implicada-en-la-regulacion-de-la-fotocarotenogenesis-en-mucor-circinelloides\/"},"modified":"2007-12-07T00:00:00","modified_gmt":"2007-12-07T00:00:00","slug":"analisis-traduccional-y-post-traduccional-de-una-proteina-implicada-en-la-regulacion-de-la-fotocarotenogenesis-en-mucor-circinelloides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/micologia\/analisis-traduccional-y-post-traduccional-de-una-proteina-implicada-en-la-regulacion-de-la-fotocarotenogenesis-en-mucor-circinelloides\/","title":{"rendered":"Analisis traduccional y post-traduccional de una proteina implicada en la regulacion de la fotocarotenogenesis en mucor circinelloides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Murcia Flores <\/strong><\/h2>\n<p>Mucor circinelloides es un hongo filamentoso que presenta diversas respuestas a la luz azul, entre ellas, la inducci\u00f3n de la bios\u00edntesis de carotenos. El gen crga, un gen inducido por luz, actua como regulador negativo de la carotenog\u00e9nesis en este hongo, ya que la deleci\u00f3n completa del gen en la estirpe silvestre conduce a una sobreacumulaci\u00f3n de carotenos en los micelios en condiciones de luz y oscuridad. El efecto represor de crga sobre la bios\u00edntesis de carotenos se lleva a cabo mediante el control de la expresi\u00f3n de los genes carotenog\u00e9nicos estructurales. La comparaci\u00f3n de la secuencia de amino\u00e1cidos de crga con secuencias depositadas en las bases de datos sugiere que la traducci\u00f3n de crga podr\u00eda comenzar en un cod\u00f3n gug localizado 201 pb aguas arriba de cod\u00f3n aug inicialmente propuesto como inicio de la traducci\u00f3n de crga. Para determinar si este cod\u00f3n gug es el iniciador de crga, se han provocado, mediante mutag\u00e9nesis dirigida, sustituciones en los codones gug y aug localizados en el extremo 5\u00c2\u00bf de crga. Estos alelos mutantes se usaron para transformar la estirpe nula para crga, y el efecto de estos alelos sobre la carotenog\u00e9nesis se compar\u00f3 con el causado tras la introducci\u00f3n del alelo silvestre. Los resultados obtenidos han permitido confirmar que el cod\u00f3n gug es el cod\u00f3n de inicio de la traducci\u00f3n de crga. La secuencia de amino\u00e1cidos deducida del gen crga muestra distintas regiones estructurales significativas: un dominio ring-finger, una se\u00f1al de localizaci\u00f3n nuclear, tramos ricos en glutaminas y un dominio de isoprenilaci\u00f3n. El dominio ring-finger y el primer tramo de poliglutaminas, son esenciales para la regulaci\u00f3n de la s\u00edntesis de carotenos por crga en m. Circinelloides. Sin embargo, la demostraci\u00f3n de que la traducci\u00f3n de la prote\u00edna crga comienza en el cod\u00f3n gug confirma la presencia de un dominio ring-finger adicional, adem\u00e1s, recientemente se ha identificado un dominio lon. Con el objetivo de caracterizar el pap<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis traduccional y post-traduccional de una proteina implicada en la regulacion de la fotocarotenogenesis en mucor circinelloides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis traduccional y post-traduccional de una proteina implicada en la regulacion de la fotocarotenogenesis en mucor circinelloides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Murcia Flores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Mar\u00eda Ruiz Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Solano mu\u00f1oz <\/li>\n<li>eduardo Espeso fernandez (vocal)<\/li>\n<li> Avalos cordero Francisco Javier (vocal)<\/li>\n<li>Marta Fontes bastos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Murcia Flores Mucor circinelloides es un hongo filamentoso que presenta diversas respuestas a la luz azul, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36606,1654,8235],"tags":[22329,84811,48558,132250,80956,8468],"class_list":["post-59880","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular-de-microorganismos","category-micologia","category-murcia","tag-avalos-cordero-francisco-javier","tag-eduardo-espeso-fernandez","tag-francisco-solano-munoz","tag-laura-murcia-flores","tag-marta-fontes-bastos","tag-rosa-maria-ruiz-vazquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59880"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59880\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}