{"id":59909,"date":"2007-12-07T00:00:00","date_gmt":"2007-12-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-sobre-la-expresion-de-los-factores-de-iniciacion-de-la-sintesis-de-proteinas-elf4e-y-elf2a-en-tumores-cerebrales\/"},"modified":"2007-12-07T00:00:00","modified_gmt":"2007-12-07T00:00:00","slug":"estudio-sobre-la-expresion-de-los-factores-de-iniciacion-de-la-sintesis-de-proteinas-elf4e-y-elf2a-en-tumores-cerebrales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/estudio-sobre-la-expresion-de-los-factores-de-iniciacion-de-la-sintesis-de-proteinas-elf4e-y-elf2a-en-tumores-cerebrales\/","title":{"rendered":"Estudio sobre la expresion de los factores de iniciacion de la sintesis de proteinas elf4e y elf2a en tumores cerebrales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Tejada Solis <\/strong><\/h2>\n<p>1.\tLos niveles de los factores de iniciaci\u00f3n de la s\u00edntesis de prote\u00ednas el f4e y elf2a no presentaron una tendencia homog\u00e9nea al aumento o al descenso en los distintos tipos de tumores cerebrales estudiados.  2.\tRespecto al estado de fosforilaci\u00f3n de dichos factores de iniciaci\u00f3n entre los distintos tipos tumorales. La fosforilaci\u00f3n de  el f2a no varia significativamente, mientras que los niveles de elf4e fosforilado son diferentes. Los m\u00e1s altos son los de los mengingiomas y los mas bajos los de los oligodendrogliomas y gliomas mixtas.  3.\tLos niveles de el f4e y el f2a son mas elevados en los meningiomas agresivos (grado ii) que en los benignos (grado i), por lo que niveles altos de estos dos factores podr\u00edan contribuir a la progresi\u00f3n tumoral.  4.\tLa localizaci\u00f3n subcelular de los factores de iniciaci\u00f3n fue distinta a cada agrupo tumoral: a)\ten los astrocitomas, tanto el f2e como elf2a se localizan en el n\u00facleo y el citoplasma, con intensidad de tinci\u00f3n similar en ambos compartimentos.  b)\ten el grupo de oligodendrogliomas y gliomas mixtos, el elf4e se localiza preferentemente en el n\u00facleo, mientras que elf2a se localiza predominantemente en el citoplasma. c)\ten los menigiomas, elf4e es fundamentalmente citoplasm\u00e1tico y respecto a elf2a encontramos diferencias seg\u00fan el grado tumora. As\u00ed la tinci\u00f3n citoplasm\u00e1tica de elf2a es intensa en los meningiomas at\u00edpicos y d\u00e9bil en los meningiomas benignos. 5.\tExiste una correlaci\u00f3n positiva de la c\u00edclica d1 con los niveles de fosforilaci\u00f3n de el f4e en los astrocitomas y de el f2a en los meningiomas por ello, en estos tumores, proponemos dos posibles mecanismo para conseguir un incremento de c\u00edclina d1 en la c\u00e9lula: a)\tun aumento de elf4e que favorecer\u00eda el transporte del mrna de la c\u00edclica d1 del n\u00facleo del citoplasma y que ocurrir\u00eda fundamentalmente en astrociomas. b)\tun aumento de elf2a, que favorecer\u00eda la traducci\u00f3n de ciertos mrnas con secuencias orf, entre los que podr\u00eda encontrarse el mrna de ciclina d1 y que servir\u00eda par explicar los  hallazgos en meningiomas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio sobre la expresion de los factores de iniciacion de la sintesis de proteinas elf4e y elf2a en tumores cerebrales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio sobre la expresion de los factores de iniciacion de la sintesis de proteinas elf4e y elf2a en tumores cerebrales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Tejada Solis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Elena Mart\u00edn Palma<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Ortu\u00f1o mirete <\/li>\n<li>Mar\u00eda del val Toledo lobo (vocal)<\/li>\n<li>roberto Figueiras mendez (vocal)<\/li>\n<li>Ana Saiz gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Tejada Solis 1. Los niveles de los factores de iniciaci\u00f3n de la s\u00edntesis de prote\u00ednas el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,347,3178],"tags":[132309,14928,23259,132307,132308,132306],"class_list":["post-59909","post","type-post","status-publish","format-standard","hentry","category-alcala","category-oncologia-clinica","category-proteinas","tag-ana-saiz-gonzalez","tag-joaquin-ortuno-mirete","tag-maria-del-val-toledo-lobo","tag-ma-elena-martin-palma","tag-roberto-figueiras-mendez","tag-sonia-tejada-solis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59909"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59909\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}