{"id":59921,"date":"2018-03-09T22:47:46","date_gmt":"2018-03-09T22:47:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-espiranos-azabica%c2%adclicos-y-decahidroquinolinas-dirigidas-a-la-preparacion-de-productos-naturales-con-el-motivo-estructural-de-1-azaspiro4-5decano\/"},"modified":"2018-03-09T22:47:46","modified_gmt":"2018-03-09T22:47:46","slug":"sa%c2%adntesis-de-espiranos-azabica%c2%adclicos-y-decahidroquinolinas-dirigidas-a-la-preparacion-de-productos-naturales-con-el-motivo-estructural-de-1-azaspiro4-5decano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-espiranos-azabica%c2%adclicos-y-decahidroquinolinas-dirigidas-a-la-preparacion-de-productos-naturales-con-el-motivo-estructural-de-1-azaspiro4-5decano\/","title":{"rendered":"S\u00edntesis de espiranos azabic\u00edclicos y decahidroquinolinas dirigidas a la preparaci\u00f3n de productos naturales con el motivo estructural de 1-azaspiro[4.5]decano"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ricou I Figuerola Mar\u00eda  Eva <\/strong><\/h2>\n<p>La presente tesis doctoral se enmarca dentro de un proyecto de s\u00edntesis de productos naturales azapolic\u00edclicos. En el transcurso de la misma se han desarrollado diversas metodolog\u00edas para la s\u00edntesis de azaspiro[4.5]decanos polifuncionalizados de forma rac\u00e9mica y enanitopura. Se ha estudiado la utilidad sint\u00e9tica de estos \u00faltimos como intermedios en la s\u00edntesis de los sistemas azatric\u00edclicos del fr901483 y las cilindricinas. Los resultados m\u00e1s significativos se obtienen con la reacci\u00f3n de haluros de vinillo sobre enolatos de cetona catalizada por paladio y la reacci\u00f3n radicalaria de tricloroacetamidas como proadicales y sililenol\u00e9teres como aceptores radicalarios. Por otra parte, se ha implantado una nueva metodolog\u00eda sint\u00e9tica concisa y vers\u00e1til para la preparaci\u00f3n de decahidroquinolinas y octahidroindoles funcionalizados basada en la iodoaminociclaci\u00f3n de bishomoalilaminas. La reacci\u00f3n de 2-alil-n-bencilciclohexilaminas con nis  permite el acceso a 3-iododecahidroquinolinas que por tratamiento con al\u00famina conducen a 3-hidroxidecahidroquinolinas y\/o 2-hidroximetiloctahidroindoles con retenci\u00f3n de configuraci\u00f3n. esta estrategia desarrollada en la \u00faltima parte de la tesis abre una nueva ruta sint\u00e9tica para acceder a los sistemas tric\u00edclcios de las cilindricinas, la fasicularina y el policitorol a trav\u00e9s de las decahidroquinolinas correspondientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de espiranos azabic\u00edclicos y decahidroquinolinas dirigidas a la preparaci\u00f3n de productos naturales con el motivo estructural de 1-azaspiro[4.5]decano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de espiranos azabic\u00edclicos y decahidroquinolinas dirigidas a la preparaci\u00f3n de productos naturales con el motivo estructural de 1-azaspiro[4.5]decano <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ricou I Figuerola Mar\u00eda  Eva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Bonjoch Sese<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pelayo Camps Garc\u00eda <\/li>\n<li>mikel Oiarbide garmendia (vocal)<\/li>\n<li>sergio Castillon miranda (vocal)<\/li>\n<li>Marta Figueredo galimany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricou I Figuerola Mar\u00eda Eva La presente tesis doctoral se enmarca dentro de un proyecto de s\u00edntesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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