{"id":59927,"date":"2018-03-09T22:47:46","date_gmt":"2018-03-09T22:47:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-administracion-de-una-fibra-insolubre-semillas-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa\/"},"modified":"2018-03-09T22:47:46","modified_gmt":"2018-03-09T22:47:46","slug":"influencia-de-la-administracion-de-una-fibra-insolubre-semillas-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/influencia-de-la-administracion-de-una-fibra-insolubre-semillas-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa\/","title":{"rendered":"Influencia de la administraci\u00f3n de una fibra insolubre (semillas de plantago ovata) en la farmacocin\u00e9tica de la levodopa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda no De La Torre Saiz <\/strong><\/h2>\n<p>En la presente memoria experimental se ha estudiado si la administraci\u00f3n de semillas de plantago ovata (fibra diet\u00e9tica insoluble) a 2 dosis diferentes modifica la biodisponibilidad y otros par\u00e1metros farmacocin\u00e9ticos de la levodopa, y estas variaciones son diferentes cuando se administra junto con carbidopa. Para el estudio experimental se han utilizado 36 conejos de raza neozeland\u00e9s blanco, distribuidos al azar en 2 lotes (i y ii) de 18 conejos cada uno. Todos los tratamientos se hicieron por v\u00eda oral. Los animales del lote i se subdividieron en 3 sublotes, de 6 animales cada uno, recibiendo levodopa en disoluci\u00f3n acuosa (20 mg\/kg), levodopa en disoluci\u00f3n acuosa (20 mg\/kg) con semillas de plantago ovata (100 mg\/kg) y levodopa en disoluci\u00f3n acuosa (20 mg\/kg) con semillas de plantago ovata (400 mg\/kg). Los animales del lote ii tambi\u00e9n fueron divididos en 3 sublotes, y recibieron: levodopa:carbidopa (20:5 mg\/kg) en forma s\u00f3lida, levodopa:carbidopa (20:5 mg\/kg) en forma s\u00f3lida y semillas de plantago ovata (100 mg\/kg), y levodopa:carbidopa (20:5 mg\/kg) en forma s\u00f3lida y semillas de plantago ovata (400 mg\/kg). tras su administraci\u00f3n se comprob\u00f3 que la cin\u00e9tica de la levodopa administrada sola, con fibra, con carbidopa, o con carbidopa y fibra, no se ajusta a ninguno de los 3 modelos compartimentales abiertos cl\u00e1sicos, describi\u00e9ndose de forma m\u00e1s adecuada con una farmacocin\u00e9tica no compartimental. La biodisponibilidad oral de la levodopa en conejos se caracteriz\u00f3 por una absorci\u00f3n baja, con una fracci\u00f3n de dosis absorbida (f) del 40,11% y una concentraci\u00f3n plasm\u00e1tica m\u00e1xima (cmax) de 1,440 \u00c2\u00b5g.Ml-1 que se alcanza de forma r\u00e1pida (10 min). Cuando se administra con carbidopa, la cantidad absorbida de levodopa pr\u00e1cticamente se triplica (f = 132,69%) y se duplica cmax (2,790 \u00c2\u00b5g.Ml-1) (diferencias significativas con respecto a los valores de levodopa sola). La velocidad de absorci\u00f3n es menor, retras\u00e1ndose tmax (20 min). Por otro lado, la admini<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la administraci\u00f3n de una fibra insolubre (semillas de plantago ovata) en la farmacocin\u00e9tica de la levodopa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la administraci\u00f3n de una fibra insolubre (semillas de plantago ovata) en la farmacocin\u00e9tica de la levodopa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda no De La Torre Saiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Vieitez Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: matilde Sierra vega <\/li>\n<li> Loro ferrer Juan  Francisco (vocal)<\/li>\n<li>asunci\u00f3n Mor\u00e1n benito (vocal)<\/li>\n<li>pilar Fresen cancino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda no De La Torre Saiz En la presente memoria experimental se ha estudiado si la administraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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