{"id":59928,"date":"2018-03-09T22:47:46","date_gmt":"2018-03-09T22:47:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-estrenimiento-y-de-una-fibra-hidrosoluble-cuta%c2%adculas-de-semilla-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa\/"},"modified":"2018-03-09T22:47:46","modified_gmt":"2018-03-09T22:47:46","slug":"influencia-del-estrenimiento-y-de-una-fibra-hidrosoluble-cuta%c2%adculas-de-semilla-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/influencia-del-estrenimiento-y-de-una-fibra-hidrosoluble-cuta%c2%adculas-de-semilla-de-plantago-ovata-en-la-farmacocinetica-de-la-levodopa\/","title":{"rendered":"Influencia del estre\u00f1imiento y de una fibra hidrosoluble (cut\u00edculas de semilla de plantago ovata) en la farmacocin\u00e9tica de la levodopa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngela Pilar Calle Pardo <\/strong><\/h2>\n<p>La levodopa es el f\u00e1rmaco m\u00e1s eficaz para el tratamiento sintom\u00e1tico de la enfermedad de parkinson. Se ha llevado a cabo un estudio experimental en conejos de raza neozeland\u00e9s blanco con el fin de comprobar si las cut\u00edculas de semilla de plantago ovata modifican los par\u00e1metros farmacocin\u00e9ticos de absorci\u00f3n y eliminaci\u00f3n de la levodopa (administrada con carbidopa y biperideno), cuando esta administraci\u00f3n se hace en condiciones de estre\u00f1imiento, situaci\u00f3n muy habitual en los pacientes de parkinson. El biperideno se ha utilizado para reducir el peristaltismo intestinal, y tambi\u00e9n se emplea en el tratamiento de los enfermos de parkinson por su acci\u00f3n anticolin\u00e9rgica, produciendo como reacci\u00f3n adversa estre\u00f1imiento precisamente por esta acci\u00f3n. Se han utilizado 36 conejos, distribuidos al azar en 3 lotes. El lote i recibi\u00f3 20 mg\/kg de levodopa por v\u00eda oral con carbidopa (5 mg\/kg) y 100  \/kg de biperideno, y los lotes ii y iii 20:5 mg\/kg de levodopa\/carbidopa, 100  \/kg de biperideno y 100 mg\/kg (lote ii) \u00f3 400 mg\/kg (lote iii) de plantago ovata, en todos los casos por v\u00eda oral. A su vez, cada uno de los 3 lotes se subdividi\u00f3 en 2 sublotes de 6 animales que se diferenciaban en la duraci\u00f3n del tratamiento (7 \u00f3 14 ). se comprob\u00f3 que la concentraci\u00f3n m\u00ednima (cmin) aumenta con la duraci\u00f3n del tratamiento en los diferentes grupos, siendo este aumento siempre significativo entre la primera (d\u00eda 3) y la \u00faltima determinaci\u00f3n (d\u00eda 7 \u00f3 14). Cmin aumenta siempre al administrar la fibra, existiendo diferencias significativas para todos los valores cuando la dosis de fibra administrada es de 400 mg\/kg, mientras que para la dosis de 100 mg\/kg el aumento fue significativo los d\u00edas 9, 11 y 14. Adem\u00e1s, cmin es mayor para la dosis m\u00e1s alta de fibra (400 mg\/kg) que para la m\u00e1s baja (100 mg\/kg). En cuanto a la concentraci\u00f3n plasm\u00e1tica m\u00e1xima (cmax), aumenta con la duraci\u00f3n del tratamiento en los diferentes grupos, siendo el aumento siempre significat<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del estre\u00f1imiento y de una fibra hidrosoluble (cut\u00edculas de semilla de plantago ovata) en la farmacocin\u00e9tica de la levodopa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del estre\u00f1imiento y de una fibra hidrosoluble (cut\u00edculas de semilla de plantago ovata) en la farmacocin\u00e9tica de la levodopa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngela Pilar Calle Pardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matilde Sierra Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis San rom\u00e1n del barrio <\/li>\n<li>eduardo Navarro Garc\u00eda (vocal)<\/li>\n<li> Hermida alonso Jos\u00e9 \u00e1ngel (vocal)<\/li>\n<li> Mart\u00edn calvo Mar\u00eda Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngela Pilar Calle Pardo La levodopa es el f\u00e1rmaco m\u00e1s eficaz para el tratamiento sintom\u00e1tico de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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