{"id":59934,"date":"2018-03-09T22:47:46","date_gmt":"2018-03-09T22:47:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-diferencial-de-genes-implicados-en-invasion-y-mestastasis-mediante-arrays-de-cdna-en-el-cancer-de-prostata-expresion-de-osteopontina-como-factor-pronostico\/"},"modified":"2018-03-09T22:47:46","modified_gmt":"2018-03-09T22:47:46","slug":"expresion-diferencial-de-genes-implicados-en-invasion-y-mestastasis-mediante-arrays-de-cdna-en-el-cancer-de-prostata-expresion-de-osteopontina-como-factor-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/expresion-diferencial-de-genes-implicados-en-invasion-y-mestastasis-mediante-arrays-de-cdna-en-el-cancer-de-prostata-expresion-de-osteopontina-como-factor-pronostico\/","title":{"rendered":"Expresi\u00f3n diferencial de genes implicados en invasi\u00f3n y mestastasis mediante arrays de cdna en el c\u00e1ncer de pr\u00f3stata: expresi\u00f3n de osteopontina como factor pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Conde Sanchez <\/strong><\/h2>\n<p>Introducci\u00f3n     el adenocarcinoma de pr\u00f3stata (acp) se caracteriza por ser una enfermedad con una importante heterogeneidad cl\u00ednica y biol\u00f3gica con complicadas dimensiones moleculares y epidemiol\u00f3gicas. A pesar de convertirse aceleradamente en un importante problema de salud a nivel mundial, a\u00fan existen dificultades para alcanzar un diagnostico y pron\u00f3stico exactos y para establecer el manejo terap\u00e9utico m\u00e1s efectivo, debido en parte a que no disponemos de un marcador de confianza para predecir la progresi\u00f3n maligna de las c\u00e9lulas cancerosas. la osteopontina (opn) es una glucoprote\u00edna fosforilada con una estructura hom\u00f3loga a las prote\u00ednas de la matriz extracelular, y que puede unirse a un gran n\u00famero de receptores, incluyendo integrinas y cd44. Su importancia, en oncolog\u00eda en general y en urolog\u00eda en particular se hace evidente en los \u00faltimos a\u00f1os, tanto por su inter\u00e9s diagn\u00f3stico como pron\u00f3stico.  objetivos, material y m\u00e9todo     analizar mediante t\u00e9cnicas de array de cdna, si existe sobre-expresi\u00f3n de genes relacionados con invasi\u00f3n y met\u00e1stasis (especialmente el gen de opn) cuando se compara un subgrupo de pacientes diagnosticados de acp localmente avanzado o metast\u00e1sico y sometidos a bloqueo hormonal con muy mala respuesta a la hormonoterapia (ht), con otro grupo de pacientes con el mismo diagn\u00f3stico y tratamiento pero con muy buena respuesta a la ht.     analizar mediante western blot si existen diferencias de expresi\u00f3n de la prote\u00edna opn cuando se compara el nivel de expresi\u00f3n de las l\u00edneas celulares hormonorrefractarias de acp (pc3 y du145) con la l\u00ednea homonosensible (lncap).     analizar mediante inmunohistoqu\u00edmica semicuantitativa sobre material de biopsia prost\u00e1tica de 50 pacientes diagnosticados de acp localmente avanzado o metast\u00e1sico y de 20 pacientes diagnosticados de hbp (como grupo control), si la expresi\u00f3n de la prote\u00edna opn se comporta como factor pron\u00f3stico y si guarda relaci\u00f3n con el fenotipo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n diferencial de genes implicados en invasi\u00f3n y mestastasis mediante arrays de cdna en el c\u00e1ncer de pr\u00f3stata: expresi\u00f3n de osteopontina como factor pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n diferencial de genes implicados en invasi\u00f3n y mestastasis mediante arrays de cdna en el c\u00e1ncer de pr\u00f3stata: expresi\u00f3n de osteopontina como factor pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Conde Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Antonio Medina L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 L\u00f3pez barnero <\/li>\n<li>Antonio Alcaraz asencio (vocal)<\/li>\n<li>Jes\u00fas Casti\u00f1eiras fern\u00e1ndez (vocal)<\/li>\n<li> Torrubia romero Francisco Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Conde Sanchez Introducci\u00f3n el adenocarcinoma de pr\u00f3stata (acp) se caracteriza por ser una enfermedad con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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