{"id":59980,"date":"2018-03-09T22:47:49","date_gmt":"2018-03-09T22:47:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-papel-de-rad52-en-la-estabilidad-genomica-de-c-albicans\/"},"modified":"2018-03-09T22:47:49","modified_gmt":"2018-03-09T22:47:49","slug":"analisis-del-papel-de-rad52-en-la-estabilidad-genomica-de-c-albicans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/extremadura\/analisis-del-papel-de-rad52-en-la-estabilidad-genomica-de-c-albicans\/","title":{"rendered":"An\u00e1lisis del papel de rad52 en la estabilidad gen\u00f3mica de c. albicans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jonathan G\u00f3mez Raja <\/strong><\/h2>\n<p>Resumen: candida albicans es un hogo comensal presente en el 50-70% de la poblaci\u00f3n que bajo determinadas circunstancias, tal como bajada en las defensas, se convierte en un pat\u00f3geno. hemos demostrado que la cepa de c. Albicans sc5314 y su derivado cai4 son heterozig\u00f3ticos para el gen his4. Dentro de la orf his4 hemos encontrado 11 snps, siete sin\u00f3nimos y cuatro no sin\u00f3nimos que definen dos haplotipos. La funcionalidad est\u00e1 determinada por la base presente en el snp929, de manera que g determina funcionalidad y t determina no funcionalidad debido a la presencia de gly310 o val310, respectivamente. Este cambio se encuentra dentro del m\u00f3dulo his4b de la prote\u00edna his4, por lo que afectar\u00eda a su actividad como fosforibosil-atp pirofosfatasa. bas\u00e1ndonos en este marcador heterozig\u00f3tico, hemos investigado la frecuencia de aparici\u00f3n de aux\u00f3trofos para la histidina como una medida de frecuencia de p\u00e9rdida de heterozigosidad en mutantes rad52-\u00c2\u00bf\u00c2\u00bf de c. Albicans. El gen rad52 en c. Albicans es absolutamente necesario para los eventos mediados por la recombinaci\u00f3n hom\u00f3loga, y su ausencia produce fuertes defectos en integraci\u00f3n hom\u00f3loga, reparaci\u00f3n de dna y mantenimiento de tel\u00f3meros. Los mutantes rad52 de c. Albicans exhiben una frecuencia media de perdida de heterozigosidad al menos 100 veces mayor que la cepa parental cai4, siendo la p\u00e9rdida de cromosoma el evento m\u00e1s com\u00fan que la origina. Adem\u00e1s, mostraron una alta frecuencia de mutaci\u00f3n puntual (al menos para la orf del gen his4). Las cepas rad52 his- seleccionadas muestran alta frecuencia de fragmentaci\u00f3n de cromosomas que no est\u00e1 relacionada con la adquisici\u00f3n de la auxotrof\u00eda. Adem\u00e1s, parece que tras la p\u00e9rdida o rotura de un cromosoma tiene lugar una duplicaci\u00f3n del hom\u00f3logo residual o del hom\u00f3logo no truncado, respectivamente. Las roturas que originan los cromosomas truncados en estas cepas parecen ser reparadas mediante la adici\u00f3n de tel\u00f3mero de novo. Estos cromosomas truncados se mantienen razonablemente estables a lo largo de varias generaciones.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis del papel de rad52 en la estabilidad gen\u00f3mica de c. albicans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis del papel de rad52 en la estabilidad gen\u00f3mica de c. albicans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jonathan G\u00f3mez Raja <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Germ\u00e1n Larriba Calle<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro (secretario) Fern\u00e1ndez salguero <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jonathan G\u00f3mez Raja Resumen: candida albicans es un hogo comensal presente en el 50-70% de la poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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