{"id":5999,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/modulacion-de-la-respuesta-inmune-por-colecistoquinina-y-gastrina\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"modulacion-de-la-respuesta-inmune-por-colecistoquinina-y-gastrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-la-respuesta-inmune-por-colecistoquinina-y-gastrina\/","title":{"rendered":"Modulacion de la respuesta inmune por colecistoquinina y gastrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Carrasco Triguero <\/strong><\/h2>\n<p>En este trabajo se ha demostrado que la colecistoquinina (cck) y la gastrina modulan negativamente la respuesta inmune \u00abin vitro\u00bb en humanos y en ratones de la cepa balb\/c. Los efectos observados dependen de la concentracion de los peptidos utilizada, siendo la mas efectiva en humanos la de 10-10m y en ratones la de 10-8m. En concreto, sobre el proceso fagocitico de los fagocitos de humano y de raton, estimulan la adherencia a sustrato, siendo inhibidores sobre la movilidad, ingestion y digestion de particulas y quimioatrayentes para los neutrofilos humanos. En cuanto a las funciones de los linfocitos, estimulan la adherencia a sustrato de los linfocitos de sangre periferica humana y de las peritoneales y de bazo de ganglios axilares y de timo de raton, inhiben la movilidad de dichos linfocitos, son quimioatrayentes para los linfocitos humanos estimulan la proliferacion espontanea de los linfocitos de las dos especies e inhiben la proliferacion inducida por el mitogeno fitohemaglutinina. Los peptidos inhiben la produccion de il-2 de los linfocitos humanos activados por mitogeno. Los efectos observados de la cck parecen ser especificos segun lo demuestra el que se vean revertidos en presencia de un antagonista de los receptores de tipo cck-a. En cuanto a los mecanismos de accion a nivel intracelular, en los fagocitos, estos peptidos producen una elevacion de los niveles intracelulares de ampc, una disminucion de los de calcio, asi como una disminucion de la actividad de la proteina quinasa c. En los linfocitos se observa una elevacion de los niveles de ampc y una disminucion de la actividad de la proteina quinasa c.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la respuesta inmune por colecistoquinina y gastrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la respuesta inmune por colecistoquinina y gastrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Carrasco Triguero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Monica De La Fuente Del Rey<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rosa Mar\u00eda Arahuetes Portero <\/li>\n<li>Javier Leceta Martinez (vocal)<\/li>\n<li>Melchor Alvarez De Mon Soto (vocal)<\/li>\n<li>Ignacio Arribas G\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Carrasco Triguero En este trabajo se ha demostrado que la colecistoquinina (cck) y la gastrina modulan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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