{"id":60011,"date":"2018-03-09T22:47:49","date_gmt":"2018-03-09T22:47:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-va%c2%ada-de-p53-en-la-induccion-de-apoptosis-por-inhibidores-de-mdm2-e-inhibidores-de-hdac-en-la-leucemia-linfoca%c2%adtica-cronica\/"},"modified":"2018-03-09T22:47:49","modified_gmt":"2018-03-09T22:47:49","slug":"implicacion-de-la-va%c2%ada-de-p53-en-la-induccion-de-apoptosis-por-inhibidores-de-mdm2-e-inhibidores-de-hdac-en-la-leucemia-linfoca%c2%adtica-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/implicacion-de-la-va%c2%ada-de-p53-en-la-induccion-de-apoptosis-por-inhibidores-de-mdm2-e-inhibidores-de-hdac-en-la-leucemia-linfoca%c2%adtica-cronica\/","title":{"rendered":"Implicaci\u00f3n de la v\u00edade p53 en la inducci\u00f3n de apoptosis por inhibidores de mdm2 e inhibidores de hdac en la leucemia linfoc\u00edtica cr\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lloren\u00c1\u00a7 Coll Mulet <\/strong><\/h2>\n<p>La llc es la forma m\u00e1s com\u00fan de leucemia en adultos en occidente. La llc se caracteriza por la acumulaci\u00f3n de linfocitos b cd5+ en sangre perif\u00e9rica y m\u00e9dula. El objetivo de esta tesis doctoral ha sido estudiar la implicaci\u00f3n de la v\u00eda p53 en la inducci\u00f3n de apoptosis por los inhibidores de mdm2 y los inhibidores de hdac en la leucemia linfoc\u00edtica cr\u00f3nica (llc). Utilizando t\u00e9cnicas como la citometr\u00eda de flujo, el estern-blot, la pcr cuantitativa y el mlpa y utilizando cultivos primarios de linfocitos de llc se han abordado los diferentes objetivos.     el estudio de los efectos de la inhibici\u00f3n de mdm2 en la llc se ha desglosado en :     1,- an\u00e1lisis de la activaci\u00f3n de p53 y la inducci\u00f3n de apoptosis en c\u00e9lulas de llc por las nutlinas, inhibidores de mdm2.     2,- estudio de la selectividad de los inhibidores de mdm2 hacia las c\u00e9lulas tumorales, la capacidad de sobrepasar alteraciones en la v\u00eda de p53 que est\u00e9n por encima de p53, y el efecto de la combinaci\u00f3n con drogas usadas en terapia que utilicen p53 para su efecto apopt\u00f3tico.     3,- identificaci\u00f3n de las dianas transcripcionales de p53 en llc mediatne el an\u00e1lisis de los perfiles de expresi\u00f3n de genes de las c\u00e9lulas de llc tras el tratamiento con inhibidores de mdm2. Y se han alcanzado las siguientes conclusiones:     1,- los inhibidores de mdm2 activan p53 e inducen apoptosis en c\u00e9lulas de llc selectivamente respecto a los linfoctios t, y esta activaci\u00f3n es independiente de atm, por lo que es una alternativa  para la activaci\u00f3n de p53 en c\u00e9lulas con alteraciones en la v\u00eda de p53 por encima de p53.     2,- la inhibici\u00f3n del mdm2 sinergiza con drogas genot\u00f3xicas en la inducci\u00f3n de apoptosis y en la activaci\u00f3n de p563 en c\u00e9lulas de llc.     3,- puma es el miembro proapopt\u00f3tico de la familia de bcl-2 cuya expresi\u00f3n incrementa tras la activaci\u00f3n selectiva de p53 con los inhibidores de mdm2 en c\u00e9lulas de llc. Tambi\u00e9n se ha comprobado que los inhbidores de mdm2<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la v\u00edade p53 en la inducci\u00f3n de apoptosis por inhibidores de mdm2 e inhibidores de hdac en la leucemia linfoc\u00edtica cr\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la v\u00edade p53 en la inducci\u00f3n de apoptosis por inhibidores de mdm2 e inhibidores de hdac en la leucemia linfoc\u00edtica cr\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lloren\u00c1\u00a7 Coll Mulet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Gil Santano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ramon Bartrons Bach <\/li>\n<li>Miguel Angel Peinado Morales (vocal)<\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<li>Dolors Colomer Pujol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lloren\u00c1\u00a7 Coll Mulet La llc es la forma m\u00e1s com\u00fan de leucemia en adultos en occidente. La [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,36483,189,940,1027],"tags":[118385,19767,5664,132533,33987,33596],"class_list":["post-60011","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-molecular","category-farmacodinamia","category-genetica-bioquimica","category-oncologia","tag-dolors-colomer-pujol","tag-joan-gil-santano","tag-lisardo-bosca-gomar","tag-llorena-coll-mulet","tag-miguel-angel-peinado-morales","tag-ramon-bartrons-bach"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60011"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60011\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60011"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60011"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}