{"id":60168,"date":"2018-03-09T22:48:00","date_gmt":"2018-03-09T22:48:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-de-la-actividad-del-proto-oncogen-vab\/"},"modified":"2018-03-09T22:48:00","modified_gmt":"2018-03-09T22:48:00","slug":"mecanismos-de-regulacion-de-la-actividad-del-proto-oncogen-vab","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/mecanismos-de-regulacion-de-la-actividad-del-proto-oncogen-vab\/","title":{"rendered":"Mecanismos de regulaci\u00f3n de la actividad del proto-oncogen vab"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Rodriguez Couceiro <\/strong><\/h2>\n<p>Las prote\u00ednas vav son factores de intercambio de nucl\u00e9otidos de guanina para las gtpasas rho\/rac. En el primer cap\u00edtulo de este trabajo, hemos caracterizado las propiedades reguladoras, catal\u00edticas y funcionales de la prote\u00edna vav de drosophila melanogaster. Estos an\u00e1lisis muestran que la prote\u00edna vav de drosophila puede desencadenar transformaci\u00f3n oncog\u00e9nica, cambio morfol\u00f3gico y aumento de la motilidad celular en c\u00e9lulas de mam\u00edfero como consecuencia de una actividad catal\u00edtica conservada. Estudios de ganancia de funci\u00f3n con moscas transg\u00e9nicas apoyan la implicaci\u00f3n de esta prote\u00edna en procesos de desarrollo embrionario dependientes del citoesqueleto como el cierre dorsal, la fusi\u00f3n de mioblastos, el desarrollo de las tr\u00e1queas y la migraci\u00f3n de varios tipos celulares. Estos resultados indican que los mecanismos intramoleculares que controlan la actividad enzim\u00e1tica de las prote\u00ednas vav se establecieron en una etapa muy temprana de la evoluci\u00f3n. el segundo cap\u00edtulo de la tesis explora el papel de vav en la translocaci\u00f3n de las gtpasas rho\/rac desde el citosol a la membrana plasm\u00e1tica. Mediante una estrategia experimental basada en la localizaci\u00f3n de vav1 en diferentes localizaciones subcelulares observamos que la localizaci\u00f3n de rac1 activada depende de la localizaci\u00f3n del factor de intercambio. As\u00ed, la asociaci\u00f3n de vav1 al golgi promueve la localizaci\u00f3n de rac1 en este org\u00e1nulo. Por el contrario, la activaci\u00f3n de rac1 por prote\u00ednas vav localizadas en el citosol, la membrana plasm\u00e1tica o el ret\u00edculo endopl\u00e1smico conduce siempre a la translocaci\u00f3n de la gtpasa a la membrana celular. Esta translocaci\u00f3n ocurre de una manera independiente de la asociaci\u00f3n al factor de intercambio o a rhogdi y requiere la estimulaci\u00f3n de rutas de transducci\u00f3n de rac1 que modulan el citoesqueleto y la agregaci\u00f3n de balsas lip\u00eddicas en la membrana plasm\u00e1tica. Estos resultados revelan un nuevo mecanismo de regulaci\u00f3n que asegura la localizaci\u00f3n adecuada de rac1 durante la se\u00f1alizaci\u00f3n celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulaci\u00f3n de la actividad del proto-oncogen vab<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulaci\u00f3n de la actividad del proto-oncogen vab <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Rodriguez Couceiro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xose Ramon Garcia Bustelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Miguel angel Santos de dios <\/li>\n<li>Miguel angel del Pozo barriuso (vocal)<\/li>\n<li>piero Crespo baraja (vocal)<\/li>\n<li>james emmanuel Castelli gair hombria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Rodriguez Couceiro Las prote\u00ednas vav son factores de intercambio de nucl\u00e9otidos de guanina para las gtpasas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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