{"id":60181,"date":"2018-03-09T22:48:00","date_gmt":"2018-03-09T22:48:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismo-de-accion-antiinflamatoria-de-5-0-desmetilnobiletina-y-derivados-del-catalpol-en-hipersensibilidad-retardada\/"},"modified":"2018-03-09T22:48:00","modified_gmt":"2018-03-09T22:48:00","slug":"mecanismo-de-accion-antiinflamatoria-de-5-0-desmetilnobiletina-y-derivados-del-catalpol-en-hipersensibilidad-retardada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-los-farmacos\/mecanismo-de-accion-antiinflamatoria-de-5-0-desmetilnobiletina-y-derivados-del-catalpol-en-hipersensibilidad-retardada\/","title":{"rendered":"Mecanismo de accion antiinflamatoria de 5-0-desmetilnobiletina y derivados del catalpol en hipersensibilidad retardada."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esperanza Bas Infante <\/strong><\/h2>\n<p>La presente tesis doctoral se ha centrado en el estudio de 5-o-desmetilnobiletina (dmn), aislado de  sideritis tragoricanum sp. Mugronensis, y los iridoides derivados del catalpol denominados escrovalentin\u00f3sido (sv) y escropoli\u00f3sido a (sc), aislados de scrophularia auriculata sp. Valentina. La selecci\u00f3n de estos tres principios se bas\u00f3 en los estudios previos realizados en los cuales se demostraron las propiedades en modelos experimentales de inflamaci\u00f3n aguda. como m\u00e9todos experimentales in vivo se han desarrollado nuevos protocolos de inflamaci\u00f3n aguda y cr\u00f3nica en rat\u00f3n, como edema agudo en pata de rat\u00f3n inducido por carragenina y fosfolipasa a2 (pla2) y dermatitis en oreja de rat\u00f3n inducida por aplicaci\u00f3n repetida de 13-acetato de 12-o-tetradecanoilforbol (tpa). Tambi\u00e9n se han desarrollado protocolos de hipersensibilidad retardada (dth) inducida por oxazolona, dinitrofluorobenceno (dnfb) y eritrocitos de cordero (srbc). En paralelo se han desarrolado diferentes t\u00e9cnicas in vitro para establecer el posible mecanismo de acci\u00f3n de los compuestos estudiados, entre las cuales destacamos la determinaci\u00f3n de la citotoxicidad, inhibici\u00f3n de la producci\u00f3n de nitritos, prostaglandina e2, leucotrieno b4 (ltb4), as\u00ed como de las enzimas que los liberan, interleucinas (il), factor de necrosis tumoral (tnf) e interfer\u00f3n (ifn) en c\u00e9lulas aisladas. Tambi\u00e9n se han desarrollado cultivos celulares de macr\u00f3fagos raw 264.7, neutr\u00f3filos y linfocitos humanos. entre los resultados y conclusiones m\u00e1s destacables se pueden citar:  a) dmn tiene propiedades antial\u00e9rgicas en diferentes modelos experimentales de dth, reduciendo la inflamaci\u00f3n y la proliferaci\u00f3n de linfocitos, afectando principalmente a la evoluci\u00f3n del ciclo celular. Su efecto antiproliferativo est\u00e1 mediado por la inhibici\u00f3n de il-1 , il-4, tnf- , ifn- , y especialmente il-2.  Adem\u00e1s, dmn incrementa la producci\u00f3n de la citocina antiinflamatoria il-10.  La actividad antiinflamatoria in vivo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismo de accion antiinflamatoria de 5-0-desmetilnobiletina y derivados del catalpol en hipersensibilidad retardada.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismo de accion antiinflamatoria de 5-0-desmetilnobiletina y derivados del catalpol en hipersensibilidad retardada. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esperanza Bas Infante <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Rios Ca\u00f1avate<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: elisa Marhuenda requena <\/li>\n<li>Juan a Benedi gonzalez (vocal)<\/li>\n<li>michael Heinrich (vocal)<\/li>\n<li>rosario Gil benso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esperanza Bas Infante La presente tesis doctoral se ha centrado en el estudio de 5-o-desmetilnobiletina (dmn), aislado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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