{"id":60207,"date":"2018-03-09T22:48:04","date_gmt":"2018-03-09T22:48:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sfas-sfasl-and-mmp-7-new-soluble-markers-of-prognosis-and-response-to-therapy-in-advanced-colorectal-cancer\/"},"modified":"2018-03-09T22:48:04","modified_gmt":"2018-03-09T22:48:04","slug":"sfas-sfasl-and-mmp-7-new-soluble-markers-of-prognosis-and-response-to-therapy-in-advanced-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/sfas-sfasl-and-mmp-7-new-soluble-markers-of-prognosis-and-response-to-therapy-in-advanced-colorectal-cancer\/","title":{"rendered":"Sfas\/sfasl and mmp-7: new soluble markers of prognosis and response to therapy in advanced colorectal cancer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Nadal Sanmart\u00edn <\/strong><\/h2>\n<p>Serum matriz metalloproteinase 7 (mmp-7)levels identifies poor prognosis acrc patients (int j cancer, 2007) mmp-7 es una enzima sintetizada por c\u00e9lulas tumorales y secretada al medio. Juega un papel importante en el crecimiento tumoral, invasi\u00f3n y diseminaci\u00f3n dada la implicaci\u00f3n de mmp-7 en la biolog\u00eda tumoral, planteamos definir el significado pron\u00f3stico de los niveles s\u00e9ricos de mmp-7 en pacientes con ccrm y explorar sus posible impacto en la pr\u00e1ctica cl\u00ednica habitual .  metodos     los niveles de mmp-7 se determinaron por t\u00e9cnica de elisa. Determinamos los niveles s\u00e9ricos de mmp-7 en 87 controles sanos, 96 pacientes con ccr no matem\u00e1tico y en 120 pacientes con ccrm. La informaci\u00f3n cl\u00ednica se extrajo de los historiales de los pacientes para crear una base de datos. El modelo \u00ab\u00bbcoa proprotional hazards\u00bb\u00bb se utiliz\u00f3 para determinar la supervivencia.  se incluyeron mmp-7 y las variables asociadas a pron\u00f3stico y se emple\u00f3 un m\u00e9todo de eliminaci\u00f3n a posterior para ajustar el modelo. El criterio de inclusi\u00f3n era p 0,05 y el de exclusi\u00f3n fue p 0,10.  resultados     los pacientes con ccrm tienen unos niveles s\u00e9ricos medios de mmp-7 significativamente m\u00e1s altos (13.4 ng\/ml) que los pacientes con ccr no metast\u00e1sico (5.5 ng\/ml, p mayor 0,001) y que los controles sanos (4.2 ng\/ml , p mayor 0,001) en los pacientes con ccrm, despu\u00e9s de ajustar para otras variables pron\u00f3sticas, mmp-7 (como variables continua) se asocia a un descenso en la supervivencia (hr 1,016, ic 95% 1.002-1.031).  conclusiones     los niveles s\u00e9ricos de mmp-7 est\u00e1n elevados de manera significativa en pacientes con ccrm. Mmp-7 es un factor pron\u00f3stico independiente para la supervivencia en ccr.  en nuestra muestra, el riesgo de muerte asociado al incremento de mmp-7 es mayor que el riesgo de muerte asociado a la elevaci\u00f3n de lactato deshidrogenasa (ldh). \u00ab\u00bbFas\/fas lignad ratio: a marker of oxaliplatin-based intrinsic anda acquired ressitance in advanced colorectal canc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sfas\/sfasl and mmp-7: new soluble markers of prognosis and response to therapy in advanced colorectal cancer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sfas\/sfasl and mmp-7: new soluble markers of prognosis and response to therapy in advanced colorectal cancer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Nadal Sanmart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Maurel Santasusana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Josep Fuster Obregon <\/li>\n<li>Montserrat Mu\u00f1oz Mateu (vocal)<\/li>\n<li>Jordi Bruix Tudo (vocal)<\/li>\n<li>Rafael Rosell Costa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Nadal Sanmart\u00edn Serum matriz metalloproteinase 7 (mmp-7)levels identifies poor prognosis acrc patients (int j cancer, 2007) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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