{"id":60237,"date":"2018-03-09T22:48:04","date_gmt":"2018-03-09T22:48:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-aplotipos-apoa52-y-hapoa53-del-gen-de-la-apoprotea%c2%adna-av-sobre-la-respuesta-lipemica-posprandial\/"},"modified":"2018-03-09T22:48:04","modified_gmt":"2018-03-09T22:48:04","slug":"efecto-de-los-aplotipos-apoa52-y-hapoa53-del-gen-de-la-apoprotea%c2%adna-av-sobre-la-respuesta-lipemica-posprandial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/efecto-de-los-aplotipos-apoa52-y-hapoa53-del-gen-de-la-apoprotea%c2%adna-av-sobre-la-respuesta-lipemica-posprandial\/","title":{"rendered":"Efecto de los aplotipos apoa5*2 y hapoa5*3 del gen de la apoprote\u00edna av, sobre la respuesta lip\u00e9mica posprandial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Moreno Luna <\/strong><\/h2>\n<p>Introducci\u00f3n     los polimorfismos -1131c\/t situado en la regi\u00f3n promotora y 56c\/g situado en el exon tercero del gen de la apoa5, modulan los niveles plasm\u00e1ticos de triglic\u00e9ridos y est\u00e1n asociados con los factores de riesgo cardiovasculares.  objetivo principal     estudiar la influencia de lso distintos haplotipos (apoa5*1 , apoa5*2 y apoa5*3) del gen de la apoa5 sobre el metabolismo lip\u00eddico postprandial.  objetivos secundarios     * determinar la influencia de los distintos polimorfismos del gen de la apoa5, tanto en el promotor (-1131t mayor c) como en el exon tercero del gen (56c mayor g), sobre la respuesta postprandial, en varones j\u00f3venes y normolipemicos apoe 3\/3.     * determinar si los polimorfismos de la apoa5, tanto en el promotor (-1131t mayor c) como en el exon 3 (56c mayor g), modifican el tama\u00f1o de las lipoproteinas de baja densidad (ldl), en respuesta al tipo y cantidad de grasa de la dieta.  personas, dise\u00f1o y m\u00e9todos     * estudio de lipemia postprandial: tras 12 horas de ayuno, 88 hombre apoe3\/3 (67 haplotipo 1 (-1131t y 56c), 12 haplotipo 2 (-1131c y 56c) y 9 haplotipo 3 (-1131t y 56g) consumieron una comida rica en grasa, realiz\u00e1ndose extracciones sangu\u00edneas previamente a la ingesta y posteriormente en las horas 1,2,3,4,5,6,8.5 y 11.     * estudio de intervenci\u00f3n diet\u00e9tica: 77 hombres y mujeres normolip\u00e9micos, apoe3\/3 (52 haplotipo 1 (-1131t y 56c), 11 haplotipo 2 (-1131c y 56c) 9 haplotipo 3 (-1131t y 56g)) fueron sometidos a tres fases de alimentaci\u00f3n de 4 semanas de duraci\u00f3n cada una. En la primera fase consumieron un elevado porcentaje de grasa saturada (sat) (38% grasa total, 20% saturada) y seguidamente se les administr\u00f3 de forma randomizada y cruzada una dieta rica en hidratos de carbono (hco) (30% grasa, menor 10% saturada, 55% hco) y otra rica en grasa monoinsaturada (mono) (38% grasa, 22% mono). Al final de cada periodo se determinaron los niveles lip\u00eddicos y el tama\u00f1o las part\u00edculas de ldl. A p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los aplotipos apoa5*2 y hapoa5*3 del gen de la apoprote\u00edna av, sobre la respuesta lip\u00e9mica posprandial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los aplotipos apoa5*2 y hapoa5*3 del gen de la apoprote\u00edna av, sobre la respuesta lip\u00e9mica posprandial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Moreno Luna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Aranda aguilar <\/li>\n<li>isaac Tunez fi\u00f1ana (vocal)<\/li>\n<li>Francisco Jos\u00e9 Fuentes  jimenez (vocal)<\/li>\n<li>Fernando Fabiani romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Moreno Luna Introducci\u00f3n los polimorfismos -1131c\/t situado en la regi\u00f3n promotora y 56c\/g situado en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,2820,139,1176],"tags":[1974,96833,101322,1613,133035,133034],"class_list":["post-60237","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-genetica-humana","category-medicina-interna","category-nutrientes","tag-enrique-aranda-aguilar","tag-fernando-fabiani-romero","tag-francisco-jose-fuentes-jimenez","tag-francisco-perez-jimenez","tag-isaac-tunez-finana","tag-rafael-moreno-luna"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60237"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60237\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}