{"id":60256,"date":"2018-03-09T22:48:04","date_gmt":"2018-03-09T22:48:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-proteina-relacionada-con-la-parathormona-como-una-nueva-citoquina-proinflamatoria-renal-estudios-en-un-modelo-experimetnal-de-nefropatia-obstructiva\/"},"modified":"2018-03-09T22:48:04","modified_gmt":"2018-03-09T22:48:04","slug":"la-proteina-relacionada-con-la-parathormona-como-una-nueva-citoquina-proinflamatoria-renal-estudios-en-un-modelo-experimetnal-de-nefropatia-obstructiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/la-proteina-relacionada-con-la-parathormona-como-una-nueva-citoquina-proinflamatoria-renal-estudios-en-un-modelo-experimetnal-de-nefropatia-obstructiva\/","title":{"rendered":"La proteina relacionada con la parathormona como una nueva citoquina proinflamatoria renal. estudios en un modelo experimetnal de nefropatia obstructiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Ramila Gutierrez <\/strong><\/h2>\n<p>La prote\u00edna relacionada con la parathormona (pthrp) se ha descrito recientemente como un posible factor promotor de la fibrosis en un modelo de nefrotoxicidad por \u00e1cido f\u00f3lico. La inflamaci\u00f3n es uno de las etapas clave en la fibrog\u00e9nesis asociada al da\u00f1o renal. En la presente tesis doctoral hemos estudiado el posible papel de la pthrp en el proceso inflamatorio tras la obstrucci\u00f3n ureteral unilateral en el rat\u00f3n, un modelo bien caracterizado de inflamaci\u00f3n renal. Para ello, utilizamos ratones transg\u00e9nicos que sobreexpresan la pthrp de forma constitutiva en las c\u00e9lulas del tubulo proximal y ratones normales sometidos a modulaci\u00f3n farmacol\u00f3gica de la expresi\u00f3n de esta prote\u00edna. Adem\u00e1s para dilucidad los mecanismos implicados en las acciones proinflamatorias de la pthrp utilizamos cultivos de c\u00e9lulas tubuloepiteliales y macr\u00f3fagos de rat\u00f3n in vitro. Nuestros resultados demuestran el papel crucial de la ptjrp en el proceso inflamatorio en le ri\u00f1\u00f3n obstruido de rat\u00f3n. La pthrp, posiblemente a trav\u00e9s del receptor com\u00fan para pth\/pthrp tipo 1, incrementa la expresi\u00f3n de varios factores proinflamatorios en las c\u00e9lulas tubuloepiteliales y promueve la migraci\u00f3n de macr\u00f3fagos. Adem\u00e1s, la activaci\u00f3n del factor nuclear-kb mediada por extracelular signal- related kinase (erk) parece ser un mecanismo importante a trav\u00e9s del cual la pthrp induce sus efectos proinflamatorios en el ri\u00f1\u00f3n. Estos hallazgos sugieren que la pthrp podr\u00eda considerarse como un nuevo marcador de inflamaci\u00f3n y\/o una diana terap\u00e9utica en la neforpatia obstructiva.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La proteina relacionada con la parathormona como una nueva citoquina proinflamatoria renal. estudios en un modelo experimetnal de nefropatia obstructiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La proteina relacionada con la parathormona como una nueva citoquina proinflamatoria renal. estudios en un modelo experimetnal de nefropatia obstructiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Ramila Gutierrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Esbrit Arguelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Egido de los rios <\/li>\n<li>felix Manzarbeitia arambarri (vocal)<\/li>\n<li>Rafael Selgas gutierrez (vocal)<\/li>\n<li>Francisco Javier Lucio caza\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Ramila Gutierrez La prote\u00edna relacionada con la parathormona (pthrp) se ha descrito recientemente como un posible 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