{"id":60269,"date":"2018-03-09T22:48:07","date_gmt":"2018-03-09T22:48:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/postnatal-modifications-of-ampa-glutamate-receptor-subunits-expression-at-the-calyx-of-held-synapse-a-model-for-high-frequency-synaptic-transmission\/"},"modified":"2018-03-09T22:48:07","modified_gmt":"2018-03-09T22:48:07","slug":"postnatal-modifications-of-ampa-glutamate-receptor-subunits-expression-at-the-calyx-of-held-synapse-a-model-for-high-frequency-synaptic-transmission","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/postnatal-modifications-of-ampa-glutamate-receptor-subunits-expression-at-the-calyx-of-held-synapse-a-model-for-high-frequency-synaptic-transmission\/","title":{"rendered":"Postnatal modifications of ampa glutamate receptor subunits expression at the calyx of held synapse, a model for high frequency synaptic transmission"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diana Hermida Mu\u00f1iz <\/strong><\/h2>\n<p>El n\u00facleo medial del cuerpo trapezoide nmct est\u00e1 implicado en la localizaci\u00f3n de los sonidos en el espacio. En este n\u00facleo, la c\u00e9lula principal recibe contactos axosom\u00e1ticos del c\u00e1liz de held, el terminal sin\u00e1ptico m\u00e1s grandes del sistema nervioso central de los mam\u00edferos. En los \u00faltimos a\u00f1os, este sistema c\u00e1liz de held-neurona principal, debido a las caracter\u00edsticas que posee, se ha convertido en foco de inter\u00e9s de numerosos estudios orientados a conocer mejor los eventos que tienen lugar, a nivel presin\u00e1ptico y postsin\u00e1ptico, en las sinapsis excitadoras.     la caracter\u00edstica principal de este sistema en su capacidad de funcionar adecuadamente durante la transmisi\u00f3n sin\u00e1ptica de alta frecuencia y preservar la sincronizaci\u00f3n de las se\u00f1ales auditivas. Por ello, la sinapsis c\u00e1liz de held-c\u00e9lula principal debe experimentar cambios durante el desarrollo, para responder a las exigentes condiciones de transmisi\u00f3n sin\u00e1ptica a las que esta sometida.     el glutamato es le neurotransmisor liberado en la sinapsis y, en este sistema, se han encontrado cambios de expresi\u00f3n de diferentes receptores glutamat\u00e9rgicos durante el desarrollo. Concretamente, los receptores ionotr\u00f3picos de glutamato glur2\/3 y glur4, est\u00e1n regulados durante el desarrollo en la sinapsis del nmct y muestran una mayor expresi\u00f3n en el adulto.     se han identificado unas especializaciones con abundantes ves\u00edculas sin\u00e1pticas, mitocondrias y zonas activas, en la parte distal del c\u00e1liz.  Estas estructuras altamente compartimentadas, podr\u00edan estar implicadas en la capacidad de este sistema de mantener una transmisi\u00f3n sin\u00e1ptica de alta frecuencia, tan importante para la sincronizaci\u00f3n de las se\u00f1ales auditivas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Postnatal modifications of ampa glutamate receptor subunits expression at the calyx of held synapse, a model for high frequency synaptic transmission<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Postnatal modifications of ampa glutamate receptor subunits expression at the calyx of held synapse, a model for high frequency synaptic transmission <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diana Hermida Mu\u00f1iz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Grandes Moreno Pedro Rolando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Juiz g\u00f3mez Jos\u00e9 manuel <\/li>\n<li>holger Taschenberger (vocal)<\/li>\n<li>enrique Salda\u00f1a fern\u00e1ndez (vocal)<\/li>\n<li>Fernando Perez cerda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diana Hermida Mu\u00f1iz El n\u00facleo medial del cuerpo trapezoide nmct est\u00e1 implicado en la localizaci\u00f3n de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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