{"id":60294,"date":"2018-03-09T22:48:07","date_gmt":"2018-03-09T22:48:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-igf-los-receptores-erbbs-y-sus-cascadas-de-transduccion-de-senales\/"},"modified":"2018-03-09T22:48:07","modified_gmt":"2018-03-09T22:48:07","slug":"el-sistema-igf-los-receptores-erbbs-y-sus-cascadas-de-transduccion-de-senales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/el-sistema-igf-los-receptores-erbbs-y-sus-cascadas-de-transduccion-de-senales\/","title":{"rendered":"El sistema igf: los receptores erbbs y sus cascadas de transducci\u00f3n de se\u00f1ales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Victoria Lopez Malpartida <\/strong><\/h2>\n<p>El c\u00e1ncer de pulm\u00f3n representa la primera causa de muerte por c\u00e1ncer en el hombre y la tercera en mujeres. Hasta el momento no existen estrategias terap\u00e9uticas adecuadas para aumentar la supervivencia y disminuir el n\u00famero de recidivas, de ah\u00ed el inter\u00e9s en estudiar nuevos genes diana implicados en su desarrollo. Los genes del sistema igf y la familia de receptores erbbs se caracterizan por su actividad mitog\u00e9nica y antiapopt\u00f3tica participando en el desarrollo y tumorig\u00e9nesis pulmonar. Hemos demostrado que la falta de igf-i en ratones mutantes provoca una mayor proliferaci\u00f3n en el pulm\u00f3n prenatal pero menor activaci\u00f3n de erk1\/2 y que la falta adicional de lif aumenta la activaci\u00f3n de erk1\/2 y akt. El estudio de la expresi\u00f3n de los genes del sistema igf y los receptores erbbs y de la activaci\u00f3n de sus rutas de se\u00f1alizaci\u00f3n intracelular en tumores de pulm\u00f3n humano de c\u00e9lula no peque\u00f1a (nsclc), se realiz\u00f3 a nivel de arn (rtpcr semicuantitativa) y prote\u00edna (western blot e inmunohistoqu\u00edmica en tissue arrays) utilizando 189 adenocarcinomas y 56 carcinomas epidermoides. Hemos demostrado que la expresi\u00f3n de los genes del sistema igf y de egfr es mayor en carcinomas epidermoides, mientras que la activaci\u00f3n de erk1\/2, akt, stat-3 y src es mayor en adenocarcinomas. Se encontraron correlaciones significativas entre la expresi\u00f3n de igf-ir y egfr y entre la expresi\u00f3n de egfr y la activaci\u00f3n de akt en adenocarcinomas. Sin embargo, en carcinomas epidermoides, la expresi\u00f3n de egfr se correlaciona con la activaci\u00f3n de stat-3, indicando una posible se\u00f1alizaci\u00f3n diferencial de egfr en ambos subtipos tumorales. La mayor incidencia de expresi\u00f3n de los marcadores correspondi\u00f3 a hombres fumadores y la menor a mujeres fumadoras, demostrando que la incidencia de expresi\u00f3n de estos genes en el c\u00e1ncer de pulm\u00f3n depende del h\u00e1bito tab\u00e1quico y del sexo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema igf: los receptores erbbs y sus cascadas de transducci\u00f3n de se\u00f1ales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema igf: los receptores erbbs y sus cascadas de transducci\u00f3n de se\u00f1ales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Victoria Lopez Malpartida <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rogelio Gonzalez sarmiento <\/li>\n<li>catalina Hernandez sanchez (vocal)<\/li>\n<li>Mar\u00eda  dolores Lude\u00f1a de la cruz (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Rojas caba\u00f1eros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Victoria Lopez Malpartida El c\u00e1ncer de pulm\u00f3n representa la primera causa de muerte por c\u00e1ncer en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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