{"id":60364,"date":"2007-07-09T00:00:00","date_gmt":"2007-07-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-los-dominios-funcionales-del-receptor-de-progesterona-en-la%c2%adneas-celulares-estables-de-cancer-de-mama\/"},"modified":"2007-07-09T00:00:00","modified_gmt":"2007-07-09T00:00:00","slug":"analisis-de-los-dominios-funcionales-del-receptor-de-progesterona-en-la%c2%adneas-celulares-estables-de-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/analisis-de-los-dominios-funcionales-del-receptor-de-progesterona-en-la%c2%adneas-celulares-estables-de-cancer-de-mama\/","title":{"rendered":"An\u00e1lisis de los dominios funcionales del receptor de progesterona en l\u00edneas celulares estables de c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Quiles Lara <\/strong><\/h2>\n<p>Los receptores esteroideos act\u00faan directamente en el n\u00facleo en la organizaci\u00f3n de la cromatina y en la actividad transcripcional de varios promotores celulares. Por otro lado, estos tienen otro efecto indirecto, menos comprendido en las rutas de transducci\u00f3n de se\u00f1ales citoplasm\u00e1ticas, afectando en \u00faltima instancia a la expresi\u00f3n g\u00e9nica. Para el receptor de progesterona (pr), la activaci\u00f3n de la ruta de mapks en respuesta a progesterona en l\u00edneas celulares de c\u00e1ncer de mama t47d es mediada por la interacci\u00f3n y activaci\u00f3n de pr sobre el receptor de estr\u00f3genos (er). Nosotros estamos interesados en distinguir entre los efectos directos de los receptores nucleares y aquellos mediados por las rutas de transducci\u00f3n de se\u00f1ales en la transcripci\u00f3n de genes en respuesta a hormona y proliferaci\u00f3n celular. Para esto, hemos expresado establemente en una l\u00ednea celular t47dy desprovista de pr, formas variantes marcadas de la isoforma b del pr, en regiones involucradas bien en la uni\u00f3n al dna(prb-dbd), o en su habilidad para interaccionar con er y activar la cascada c-src\/erk (prberid).  como esper\u00e1bamos, el mutante prb-dbd ha perdido su capacidad para unirse y activar el promotor reportero mouse mammary tumor virus (mmtv), y prb-erid es incapaz de inducir proliferaci\u00f3n celular en respuesta a progesterona. Un mutante adicional, prb-af2, previamente descrito como incapaz de reclutar coactivadores para la regulaci\u00f3n del promotor mmtv, tambi\u00e9n ha sido probado. La expresi\u00f3n g\u00e9nica en respuesta a progesterona en l\u00edneas celulares expresando los prb salvaje y mutantes ha sido estudiada por hibridaciones en un microarray personalizado conteniendo el cdna de 750 genes de c\u00e1ncer de mama. Nuestros resultados definen conjuntos de genes regulados en respuesta a hormona por los diferentes modos de acci\u00f3n del prb, tambi\u00e9n genes d\u00f3nde las rutas nucleares y no gen\u00f3micas cooperan. Los resultados han sido extensamente validados por rt pcr en tiempo real en experimen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de los dominios funcionales del receptor de progesterona en l\u00edneas celulares estables de c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de los dominios funcionales del receptor de progesterona en l\u00edneas celulares estables de c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Quiles Lara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Beato Del Rosal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel (secretario) Valverde de castro <\/li>\n<li>domingo Barettino fraile (vocal)<\/li>\n<li>f\u00e1tima Gebauer hern\u00e1ndez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Quiles Lara Los receptores esteroideos act\u00faan directamente en el n\u00facleo en la organizaci\u00f3n de la cromatina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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