{"id":60441,"date":"2018-03-09T22:48:15","date_gmt":"2018-03-09T22:48:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/indicadores-biologicos-de-dano-oxidativo-por-radicales-libres-enpacientes-sometidos-a-extirpacion-quirurgica-de-tumores-cerebrales\/"},"modified":"2018-03-09T22:48:15","modified_gmt":"2018-03-09T22:48:15","slug":"indicadores-biologicos-de-dano-oxidativo-por-radicales-libres-enpacientes-sometidos-a-extirpacion-quirurgica-de-tumores-cerebrales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/indicadores-biologicos-de-dano-oxidativo-por-radicales-libres-enpacientes-sometidos-a-extirpacion-quirurgica-de-tumores-cerebrales\/","title":{"rendered":"Indicadores biol\u00f3gicos de da\u00f1o oxidativo por radicales libres, enpacientes sometidos a extirpaci\u00f3n quir\u00fargica de tumores cerebrales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Zumero Imaz Mar\u00eda Jos\u00e9 <\/strong><\/h2>\n<p>Studio realizado en 57 pacientes (27 hombres y 30 mujeres) con una media de edad de56,6 +\/- 2,0 a\u00f1os, sometidos a extirpaci\u00f3n quir\u00fargica de tumores intracraneales en el hospitalcl\u00ednico universitario \u00ablozano blesa\u00bb de zaragoza. Se distribuyeron en cuatro grupos seg\u00fanla estirpe anatomopatol\u00f3gica del tumor: i,gliomas, li,meningiomas, iii, met\u00e1stasis, iv, otros.En muestras de suero sangu\u00edneo, l\u00edquido cefalorraquideo (lcr) y tejido tumoral y peritumoral,se estudi\u00f3 el grado de lesi\u00f3n oxidativa por radicales libres (rl), valorando: la actividad totalantioxidante (tas) en lcr y suero,el grado peroxidaci\u00f3n lip\u00eddica midiendo elmalonildialdeh\u00eddo y 4-hidroxialquenales (mda+4-hda) en suero y tejidos tumoral yperitumoral, la lesi\u00f3n a prote\u00ednas cuantificando restos carbonilo en suero y tejidos tumoral yperitumoral y la modificaci\u00f3n de fluidez de membrana por acci\u00f3n oxidativa de los tejidostumoral y peritumoral.Entre los resultados obtenidos destacan:- los valores de tas s\u00e9ricos y en lcr no presentaron diferencias entre los distintos grupos.- Los niveles de mda+4hda s\u00e9ricos fueron semejantes en los 57 casos sin diferenciasentre sexos o estirpe tumoral. En tejido tumoral fueron superiores con significaci\u00f3n en losgrupos de tumores m\u00e1s invasivos, gliomas y met\u00e1stasis respecto a meningiomas.No existieron diferencias entre grupos en el tejido peritumoral siendo los valores demda+4-hda superiores a los del tejido tumoral.- Los restos carbonilo s\u00e9ricos fueron semejantes en los distintos grupos, sin diferencias por elsexo o tipo de tumor. En tejido tumoral hubo significativamente mayor carbonilaci\u00f3n prot\u00e9icaen el grupo de tumores de origen extraneural, seguido de los meningiomas que tambi\u00e9nobtuvieron diferencias frente a los gliomas. En los grupos de meningiomas, met\u00e1stasis y otros,la carbonilaci\u00f3n prot\u00e9ica fu\u00e9 mayor en el tejido tumoral que en el peritumoral aunque sindiferencia estad\u00edstica; en el estudio por sexos solo se detectaron cambios en el caso de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Indicadores biol\u00f3gicos de da\u00f1o oxidativo por radicales libres, enpacientes sometidos a extirpaci\u00f3n quir\u00fargica de tumores cerebrales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Indicadores biol\u00f3gicos de da\u00f1o oxidativo por radicales libres, enpacientes sometidos a extirpaci\u00f3n quir\u00fargica de tumores cerebrales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Zumero Imaz Mar\u00eda Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Garcia Jos\u00e9 Joaquin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Calatayud maldonado <\/li>\n<li>Antonio Molina carballo (vocal)<\/li>\n<li>Antonio Mu\u00f1oz hoyos (vocal)<\/li>\n<li>Javier Miana mena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zumero Imaz Mar\u00eda Jos\u00e9 Studio realizado en 57 pacientes (27 hombres y 30 mujeres) con una media [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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