{"id":60488,"date":"2018-03-09T22:48:18","date_gmt":"2018-03-09T22:48:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-hormonas-esteroides-sobre-la-expresion-de-los-retrovirus-felinos\/"},"modified":"2018-03-09T22:48:18","modified_gmt":"2018-03-09T22:48:18","slug":"efecto-de-las-hormonas-esteroides-sobre-la-expresion-de-los-retrovirus-felinos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-hormonas-esteroides-sobre-la-expresion-de-los-retrovirus-felinos\/","title":{"rendered":"Efecto de las hormonas esteroides sobre la expresi\u00f3n de los retrovirus felinos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Tejerizo S\u00e1ez Jos\u00e9 Germ\u00e1n <\/strong><\/h2>\n<p>Tras analizar los resultados obtenidos en un estudio seroepidemiol\u00f3gico de los retrovirus felinos felv y fiv se detectaron diferencias que suger\u00edan que el sexo del animal puede influir en el desarrollo de la infecci\u00f3n por felv y fiv. El objetivo de este trabajo fue la detecci\u00f3n y an\u00e1lisis de interacciones entre los retrovirus felinos y las hormonas esteroides.  analizamos los niveles s\u00e9ricos de estradiol, progesterona, testosterona, dhea y cortisol en gatos, machos y hembras infectados o sin infectar. En animales infectados se detectaron incrementos en las concentraciones de estradiol, testosterona y cortisol, y descensos  en los de dhea.  para determinar si la variaci\u00f3n en las concentraciones de las hormonas puede afectar a la replicaci\u00f3n y expresi\u00f3n de prote\u00ednas de los virus, se cultivaron c\u00e9lulas linfoides infectadas con cada uno de los virus y se incubaron en presencia de distintas concentraciones de hormonas. Se determinaron la muerte celular y apoptosis, y la actividad de la transcriptasa inversa (rt) y prote\u00ednas de la c\u00e1pside en los sobrenadantes celulares. En general, concentraciones elevadas de hormonas (excepto la testosterona) favorec\u00edan el porcentaje de muerte celular y apoptosis, reprim\u00edan la actividad rt e incrementaban la presencia de prote\u00ednas v\u00edricas. La represi\u00f3n de la actividad rt y el incremento de prote\u00ednas v\u00edricas (principalmente en felv) a elevadas concentraciones de hormona se correlacion\u00f3 con la apoptosis. En el caso de fiv, portador de genes reguladores adicionales y mayor complejidad biol\u00f3gica, las relaciones entre los distintos par\u00e1metros v\u00edricos y celulares fueron menos acusadas, y sugiere la participaci\u00f3n de otros componentes.  algunos retrovirus (entre ellos felv) poseen en la regi\u00f3n reguladora de su genoma un hre. Se clon\u00f3 la secuencia promotora\/reguladora ltr (de felv o de fiv) en un vector portador de gfp, y se analiz\u00f3 su expresi\u00f3n dirigida por ltr en c\u00e9lulas transfectadas e incubadas en presencia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de las hormonas esteroides sobre la expresi\u00f3n de los retrovirus felinos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de las hormonas esteroides sobre la expresi\u00f3n de los retrovirus felinos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Tejerizo S\u00e1ez Jos\u00e9 Germ\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>lucia Duato Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Illera del portal <\/li>\n<li>Rafael Fern\u00e1ndez mu\u00f1oz (vocal)<\/li>\n<li> De Andr\u00e9s cara dami\u00e1n ferm\u00edn (vocal)<\/li>\n<li>cecilio L\u00f3pez gal\u00edndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tejerizo S\u00e1ez Jos\u00e9 Germ\u00e1n Tras analizar los resultados obtenidos en un estudio seroepidemiol\u00f3gico de los retrovirus felinos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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