{"id":60526,"date":"2018-03-09T22:48:22","date_gmt":"2018-03-09T22:48:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-celular-y-molecular-en-cultivos-de-fibroblastos-tratados-con-farmacos-inductores-de-agrandamiento-gingival\/"},"modified":"2018-03-09T22:48:22","modified_gmt":"2018-03-09T22:48:22","slug":"estudio-celular-y-molecular-en-cultivos-de-fibroblastos-tratados-con-farmacos-inductores-de-agrandamiento-gingival","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/estudio-celular-y-molecular-en-cultivos-de-fibroblastos-tratados-con-farmacos-inductores-de-agrandamiento-gingival\/","title":{"rendered":"Estudio celular y molecular en cultivos de fibroblastos tratados con farmacos inductores de agrandamiento gingival"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Albert Ramirez Ramiz <\/strong><\/h2>\n<p>Seg\u00fan los primeros casos aparecido de agrandamiento gingival farmacol\u00f3gico, por fenito\u00edna, nifedipina, ciclosporina se consideraba que se produ\u00edca un hiperplasia secundaria a la proliferaci\u00f3n celular de los fibroblastos.     la hipotesis alternativa del estudio est\u00e1 en demostrar que:     los f\u00e1rmacos inductores de agrandamiento gingival no provocan una hiperplasia secundaria a la proliferaci\u00f3n evaluar de los fibroblastos.     los objetivos del estudio son:     1,- determinar si cultivos de fibroblastos de enc\u00eda humana son sensibles a la acci\u00f3n de f\u00e1rmacos inductores de agrandamiento gingival.     2,- observar el efecto de estos f\u00e1rmacos en cultivos primarios de fibroblastos procedentes de las muestras examinadas estudio de la viabilidad celular.     3,- cuantificar si hay efecto farmacol\u00f3gico en la transcripci\u00f3n g\u00e9nica del factor de crecimiento transformador beta (tgfbeta), del col\u00e1geno y de la colagenasa.     4,- observar si hay efecto farmacol\u00f3gico en la s\u00edntesis del col\u00e1geno y del tgfbeta.  material y metodos     se tomaron muestras de enc\u00eda humana en cirug\u00edas periodontales, un sin haber recibido ning\u00fan f\u00e1rmaco inductor y la otra procedente de un pacientes transplantado que estaba sometido a tratamiento con ciclosporina. Se cultivaron las muestras y se hicieron estudios de viabilidad celular y posteriormente, en las prote\u00ednas de la matriz, col\u00e1geno, colagenasa y factor de crecimiento transformador beta se estudi\u00f3 su expresi\u00f3n de mrna y la s\u00edntesis proteica.  resultados     no se obtuvieron aumentos de crecimiento celular de los fibroblastos cultivados. La expresi\u00f3n del mrna aument\u00f3 para los tres f\u00e1rmacos con alg\u00fan resultado significativo, y la traducci\u00f3n proteica del col\u00e1geno no permiti\u00f3 cambios.  conclusiones     1,- los fibroblastos gingivales de cultivos primarios son sensibles a f\u00e1rmacos inductores de agrandamiento gingival fenito\u00edna, nifedipina y ciclosporina.     2,- los f\u00e1rmacos inductores d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio celular y molecular en cultivos de fibroblastos tratados con farmacos inductores de agrandamiento gingival<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio celular y molecular en cultivos de fibroblastos tratados con farmacos inductores de agrandamiento gingival <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Albert Ramirez Ramiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Enrique Perez Tomas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: leonardo Berini aytes <\/li>\n<li> Serra beltran miquel angel (vocal)<\/li>\n<li>lLuis Brunet llobet (vocal)<\/li>\n<li>lLuis Giner tarrida (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Albert Ramirez Ramiz Seg\u00fan los primeros casos aparecido de agrandamiento gingival farmacol\u00f3gico, por fenito\u00edna, nifedipina, ciclosporina se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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