{"id":60575,"date":"2018-03-09T22:48:25","date_gmt":"2018-03-09T22:48:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/validacion-inmunohistoqua%c2%admica-de-los-perfiles-globales-de-expresion-genica-en-mesotelioma-pleural-analisis-etiopatogenico-del-virus-sv40-y-de-la-protea%c2%adna-p16\/"},"modified":"2018-03-09T22:48:25","modified_gmt":"2018-03-09T22:48:25","slug":"validacion-inmunohistoqua%c2%admica-de-los-perfiles-globales-de-expresion-genica-en-mesotelioma-pleural-analisis-etiopatogenico-del-virus-sv40-y-de-la-protea%c2%adna-p16","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/validacion-inmunohistoqua%c2%admica-de-los-perfiles-globales-de-expresion-genica-en-mesotelioma-pleural-analisis-etiopatogenico-del-virus-sv40-y-de-la-protea%c2%adna-p16\/","title":{"rendered":"Validaci\u00f3n inmunohistoqu\u00edmica de los perfiles globales de expresi\u00f3n g\u00e9nica en mesotelioma pleural. an\u00e1lisis etiopatog\u00e9nico del virus sv40 y de la prote\u00edna p16."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Garc\u00eda Garc\u00eda <\/strong><\/h2>\n<p>El mesotelioma pleural es una neoplasia de baja incidencia pero con un manejo diagn\u00f3stico y terap\u00e9utico dif\u00edcil, asociado a una mortalidad elevada. Estas caracter\u00edsticas hacen necesario un abordaje multidisciplinar en el estudio de esta neoplasia. El desarrollo de la biolog\u00eda molecular y su aplicaci\u00f3n en el estudio de las alteraciones gen\u00e9ticas en el mesotelioma ha permitido identificar marcadores moleculares de especial relevancia por sus implicaciones biol\u00f3gicas, diagn\u00f3sticas, pron\u00f3sticas y predictivas. Implicaciones biol\u00f3gicas: aunque el amianto es el principal agente etiol\u00f3gicodel mesotelioma pleural, se ha propuesto recientemente que el virus sv40 podr\u00eda estar tambi\u00e9n implicado en su patogenia, bas\u00e1ndose en resultados de pcr que nohan sido validados por rigurosas t\u00e9cnicas de inmunohistoqu\u00edmica. En nuestra serie de mesoteliomas pleurales humanos, hemos demostrado la ausencia de expresi\u00f3n del virus sv40, utilizando dos anticuerpos de inmunohistoqu\u00edmica frente a la regi\u00f3n carboxi-terminal y amino-terminal respectivamente. Implicaciones diagn\u00f3sticas: la alteraci\u00f3n gen\u00e9tica m\u00e1s frecuente en el mesotelioma pleural es la delecci\u00f3n homocigota de la regi\u00f3n 9p21 que afecta al gen p16. En la presente tesis, el estudio mediante t\u00e9cnica de fish de la delecci\u00f3n homocigota de este gen nos ha permitido diferenciar la hiperplasia mesotelial reactiva del mesotelioma. Implicaciones pron\u00f3sticas: la determinaci\u00f3n mediante t\u00e9cnica de inmunohistoqu\u00edmica de la sobreexpresi\u00f3n prot\u00e9ica de p16 permite identificar a un subgrupo de pacientes con mesotelioma pleural con mejor pron\u00f3stico. La importancia de este hallazgo no s\u00f3lo se limita en virtud del pron\u00f3stico del paciente sino que nos permite seleccionar a un subgrupo de pacientes portadores de esta alteraci\u00f3n subsidiarios de beneficiarse del tratamiento con nuevas terapias dirigidas. Implicaciones terap\u00e9utica: el conocimiento m\u00e1s preciso de las alteraciones moleculares de una gran diversidad de neo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Validaci\u00f3n inmunohistoqu\u00edmica de los perfiles globales de expresi\u00f3n g\u00e9nica en mesotelioma pleural. an\u00e1lisis etiopatog\u00e9nico del virus sv40 y de la prote\u00edna p16.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Validaci\u00f3n inmunohistoqu\u00edmica de los perfiles globales de expresi\u00f3n g\u00e9nica en mesotelioma pleural. an\u00e1lisis etiopatog\u00e9nico del virus sv40 y de la prote\u00edna p16. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Garc\u00eda Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00ednez Tello Francisco Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mart\u00ednez tello Francisco jos\u00e9 <\/li>\n<li>Jos\u00e9 Manuel Cuezva marcos (vocal)<\/li>\n<li>montserrat S\u00e1nchez c\u00e9spedes (vocal)<\/li>\n<li>\u00e1ngel L\u00f3pez e. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Garc\u00eda Garc\u00eda El mesotelioma pleural es una neoplasia de baja incidencia pero con un manejo diagn\u00f3stico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[133775,100982,15221,92554,75587],"class_list":["post-60575","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-angel-lopez-e","tag-elena-garcia-garcia","tag-jose-manuel-cuezva-marcos","tag-Martinez-tello-francisco-jose","tag-montserrat-sanchez-cespedes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60575"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60575\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}