{"id":60645,"date":"2018-03-09T22:48:29","date_gmt":"2018-03-09T22:48:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-geneticas-inestabilidad-cromosomica-y-plasticidad-fenota%c2%adpica-durante-la-progresion-maligna-de-carcinomas-epidermoides\/"},"modified":"2018-03-09T22:48:29","modified_gmt":"2018-03-09T22:48:29","slug":"alteraciones-geneticas-inestabilidad-cromosomica-y-plasticidad-fenota%c2%adpica-durante-la-progresion-maligna-de-carcinomas-epidermoides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/alteraciones-geneticas-inestabilidad-cromosomica-y-plasticidad-fenota%c2%adpica-durante-la-progresion-maligna-de-carcinomas-epidermoides\/","title":{"rendered":"Alteraciones gen\u00e9ticas, inestabilidad cromos\u00f3mica y plasticidad fenot\u00edpica durante la progresi\u00f3n maligna de carcinomas epidermoides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar Pons Parra <\/strong><\/h2>\n<p>La transici\u00f3n de carcinoma epidermoide (scc) a carcinoma fusocelular (spcc) es el \u00faltimo estad\u00edo de la progresi\u00f3n maligna en la carcinog\u00e9nesis de piel de rat\u00f3n. Este proceso implica una conversi\u00f3n epitelio-mes\u00e9nquima mediante la cual las c\u00e9lulas tumorales adquieren caracter\u00edsticas muy agresivas y metast\u00e1sicas. En esta tesis, hemos caracterizado un modelo celular in vitro que reproduce la transici\u00f3n scc-spcc. En este modelo hemos analizado alteraciones gen\u00e9ticas espec\u00edficas y aberraciones cromos\u00f3micas implicadas en la transici\u00f3n carcinoma epidermoide-carcinoma fusocelular. aislamos una subpoblaci\u00f3n epitelial (carc-r) de la l\u00ednea de carcinoma fusocelular carc. Carc-r mostr\u00f3 una dr\u00e1stica reducci\u00f3n de las propiedades tumorog\u00e9nicas en comparaci\u00f3n con carc, pero present\u00f3 plasticidad fenot\u00edpica, ya que indujo tumores indiferenciados en ratones. A partir de un explante de un tumor inducido por carc-r (carc-rt) aislamos clones con morfolog\u00eda epitelial o fibrobl\u00e1stica. Todas las l\u00edneas celulares del modelo celular carc\/carc-r conten\u00edan la misma mutaci\u00f3n en el codon 61 del gen h-ras. Sin embargo, mientras que las c\u00e9lulas carc-r y los clones carc-rt reten\u00edan el alelo normal de h-ras, la l\u00ednea fusocelular carc lo hab\u00eda perdido. No obstante, tanto la dosis g\u00e9nica como la expresi\u00f3n de h-ras oncog\u00e9nico vs h-ras normal aumentaban en los clones carc-rt fusocelulares m\u00e1s agresivos. El an\u00e1lisis del estatus y la expresi\u00f3n del locus ink4a, que codifica los reguladores del ciclo celular p16ink4a y p19arf, revel\u00f3 que durante la progresi\u00f3n maligna ocurre la inactivaci\u00f3n secuencial de p16ink4a y p19arf, siendo la p\u00e9rdida de p19arf uno de los eventos finales relacionados con la adquisici\u00f3n de un fenotipo plenamente maligno. Los estudios mediante interferencia de rna revelaron que la inactivaci\u00f3n de p19arf, tanto en queratinocitos que contienen p53 funcional como en queratinocitos con  p53 inactivado, conduce a una transici\u00f3n epitelio-mes\u00e9nquima<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones gen\u00e9ticas, inestabilidad cromos\u00f3mica y plasticidad fenot\u00edpica durante la progresi\u00f3n maligna de carcinomas epidermoides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones gen\u00e9ticas, inestabilidad cromos\u00f3mica y plasticidad fenot\u00edpica durante la progresi\u00f3n maligna de carcinomas epidermoides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar Pons Parra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Quintanilla Avila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Garesse alarc\u00f3n <\/li>\n<li>ignacio Palmero rodriguez (vocal)<\/li>\n<li>Jos\u00e9 Fernandez piqueras (vocal)<\/li>\n<li>Manuel Collado rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar Pons Parra La transici\u00f3n de carcinoma epidermoide (scc) a carcinoma fusocelular (spcc) es el \u00faltimo estad\u00edo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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