{"id":60669,"date":"2018-03-09T22:48:29","date_gmt":"2018-03-09T22:48:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-cacwt1-de-candida-albicans-homologo-al-factor-de-transcripcion-rds2-de-saccharomyces-cerevisae\/"},"modified":"2018-03-09T22:48:29","modified_gmt":"2018-03-09T22:48:29","slug":"estudio-de-cacwt1-de-candida-albicans-homologo-al-factor-de-transcripcion-rds2-de-saccharomyces-cerevisae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-cacwt1-de-candida-albicans-homologo-al-factor-de-transcripcion-rds2-de-saccharomyces-cerevisae\/","title":{"rendered":"\u00abestudio de cacwt1 de candida albicans hom\u00f3logo al factor de transcripci\u00f3n rds2 de saccharomyces cerevisae\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Moreno Gimeno <\/strong><\/h2>\n<p>Candida albicans es el principal hongo pat\u00f3geno en el ser humano, principalmente en pacientes en los que su sistema inmunitario esta comprometido. En la actualidad la candidiasis invasiva es la causa mas com\u00fan de infecciones nosocomiales, asociada a una mortalidad del 40%. C. Albicans es un hongo polimorfico que presenta la facultad de crecer como levadura, hifa y pseudohifa. uno de los aspectos por los que c. Albicans puede comportarse como comensal o como agente pat\u00f3geno es su capacidad para responder a los cambios del medio ambiente. Para comprender los mecanismos de adaptaci\u00f3n en hongos pat\u00f3genos a los cambios ambientales cont\u00ednuos dentro del ser humano, es especialmente importante que factores transcripcionales y\/o mediadores est\u00e9n implicados. Mediante un an\u00e1lisis in silico del genoma de c. Albicans, se han detectado 70 te\u00f3ricos factores transcripcionales de la familia zn(ii)2cys6. Uno de ellos, ipf3781 (a partir de aqui cwt1), se eligio para su estudio dada la elevada homolog\u00eda que presenta con el factor de transcripci\u00f3n rds2 de saccharomyces cerevisiae. El an\u00e1lisis fenot\u00edpico del mutante nulo cwt1\/cwt1 indica de cwt1 est\u00e1 implicado en la arquitectura de la pared celular de c. Albicans, asi como en la morfog\u00e9nesis de esta levadura, sobre todo en medios s\u00f3lidos. Adicionalmente a los estudios sobre pared celular realizados, se ha estudiado la expresi\u00f3n y regulaci\u00f3n, mediante micromatrices de adn, de diferentes genes en las fases exponencial y estacionaria de la curva de crecimiento con el fin de poder elucidar m\u00e1s feacientemente el papel de cwt1. Un total de 460 genes en fase exponencial y 666 genes en fase estacionaria ten\u00edan alterada su expresi\u00f3n, de los que 121 genes eran comunes a ambas fases de crecimiento de la levadura. Este distinto perfil transcripcional podr\u00eda explicar el pleiotropismo encontrado en el mutante nulo cwt1\/cwt1. El estudio in silico de las regiones promotoras de los genes, cuya expresi\u00f3n estaba alterada, indica que<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abestudio de cacwt1 de candida albicans hom\u00f3logo al factor de transcripci\u00f3n rds2 de saccharomyces cerevisae\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abestudio de cacwt1 de candida albicans hom\u00f3logo al factor de transcripci\u00f3n rds2 de saccharomyces cerevisae\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Moreno Gimeno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/09\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eulogio Valent\u00edn L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Herrero perpi\u00f1an <\/li>\n<li>Antonio Marcilla d\u00edaz (vocal)<\/li>\n<li>joachim Ernst (vocal)<\/li>\n<li>Juan  Carlos Arguelles ordo\u00f1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Moreno Gimeno Candida albicans es el principal hongo pat\u00f3geno en el ser humano, principalmente en pacientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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