{"id":60732,"date":"2007-02-10T00:00:00","date_gmt":"2007-02-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-genes-de-la-metastasis-hepatica-de-cancer-de-colon-regulados-por-factores-microambientales-del-higado\/"},"modified":"2007-02-10T00:00:00","modified_gmt":"2007-02-10T00:00:00","slug":"estudio-de-los-genes-de-la-metastasis-hepatica-de-cancer-de-colon-regulados-por-factores-microambientales-del-higado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/estudio-de-los-genes-de-la-metastasis-hepatica-de-cancer-de-colon-regulados-por-factores-microambientales-del-higado\/","title":{"rendered":"Estudio de los genes de la metastasis hepatica de cancer de colon regulados por factores microambientales del higado"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amaya Del Villar Alvarez <\/strong><\/h2>\n<p>La met\u00e1stasis es la principal causa de muerte de pacientes con c\u00e1ncer. El h\u00edgado es uno de los \u00f3rganos predilectos en la met\u00e1stasis del c\u00e1ncer de colon, pero a\u00fan est\u00e1n por esclarecerse los mecanismos moleculares que regulan dicho proceso de met\u00e1stasis. El transcriptoma de las c\u00e9lulas tumorales que forman met\u00e1stasis hep\u00e1ticas en los pacientes con c\u00e1ncer de colon podr\u00eda contener genes regulados, por factores liberados en su entorno, por hepatocitos y miofibroblastos, activados por el propio tumor. El primer objetivo de este estudio consisti\u00f3 en la creaci\u00f3n de un modelo de cultivo de c\u00e1ncer de colon humano para reproducir ex vivo la regulaci\u00f3n de los genes que se expresan en las c\u00e9lulas del c\u00e1ncer de colon durante su crecimiento como met\u00e1stasis en el h\u00edgado de pacientes. Y el segundo objetivo de este estudio consisti\u00f3 en la identificaci\u00f3n de las condiciones funcionales reguladoras de los genes que expresan las c\u00e9lulas del c\u00e1ncer de colon en el h\u00edgado de pacientes de met\u00e1stasis hep\u00e1tica, &#8211; la regulaci\u00f3n por factores solubles liberados por c\u00e9lulas del tejido hep\u00e1tico activas por factores soluble procedentes de c\u00e9lulas tumorales, la regulaci\u00f3n por endotoxinas bacterianas (lps) &#8211; y el an\u00e1lisis transcript\u00f3mico de c\u00e9lulas ht-29 tratadas con factores solubles de c\u00e9lulas hep\u00e1ticas en cultivo primario.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los genes de la metastasis hepatica de cancer de colon regulados por factores microambientales del higado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los genes de la metastasis hepatica de cancer de colon regulados por factores microambientales del higado <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amaya Del Villar Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Vidal Vanaclocha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio Garc\u00eda herdugo <\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<li>Rafael De llorens duran (vocal)<\/li>\n<li>bonifacio nicol\u00e1s Diaz chico (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amaya Del Villar Alvarez La met\u00e1stasis es la principal causa de muerte de pacientes con c\u00e1ncer. El [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1989,1027,12909],"tags":[134140,16660,12983,11100,53895,18819],"class_list":["post-60732","post","type-post","status-publish","format-standard","hentry","category-cultivo-de-tejidos","category-oncologia","category-pais-vasco-euskal-herriko-unibertsitatea","tag-amaya-del-villar-alvarez","tag-bonifacio-nicolas-diaz-chico","tag-fernando-vidal-vanaclocha","tag-gregorio-garcia-herdugo","tag-jesus-garcia-foncillas-lopez","tag-rafael-de-llorens-duran"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60732"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60732\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}