{"id":60742,"date":"2007-03-10T00:00:00","date_gmt":"2007-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antiphospholipid-syndrome-expanding-the-spectrum-of-autoimmune-trhombosis\/"},"modified":"2007-03-10T00:00:00","modified_gmt":"2007-03-10T00:00:00","slug":"antiphospholipid-syndrome-expanding-the-spectrum-of-autoimmune-trhombosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/psicologia\/antiphospholipid-syndrome-expanding-the-spectrum-of-autoimmune-trhombosis\/","title":{"rendered":"Antiphospholipid syndrome: expanding the spectrum of autoimmune trhombosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Puerta Jos\u00e9 Alfredo <\/strong><\/h2>\n<p>El s\u00edndrome antifosfolip\u00eddico saf es una enfermedad autoinmune caracterizada pro trombosis venosas o arteriales recurrentes, p\u00e9rdidas fetales y tromobocitopenia asociadas con la presencia de los anticuerpos antifosfolip\u00eddicos aaf incluyendo los anticuerpos anticardiolipina y el anticoagulante l\u00fapico. El saf fue descrito inicialmente en pacientes afectos de lupus eritematoso sist\u00e9mico les, pero posteriormente fue descrito en pacientes sin ninguna enfermedad autoinmune de base y se conoce como saf primario. Adicionalmente el saf puede presentarse en relaic\u00f3n a otros procesos cr\u00f3nicos como las neoplasias. Finalmente existe una forma inusual de presentaci\u00f3n de saf que se caracteriza por la r\u00e1pida aparici\u00f3n de trombosis de predominio de la microvasuculatura y afectaci\u00f3n multiorg\u00e1nica conocida como saf catastr\u00f3fico.     nuestra hip\u00f3tesis es que el saf es una entidad con un amplio espectro de manifestaciones cl\u00ednicas incluyendo entre tras una variedad \u00abprimaria\u00bb que ocasionalmente evoluciona a un les, una variedad asociada a proceso neopl\u00e1sicos (tanto tumores s\u00f3lidos como neoplasias hematol\u00f3gicas) y una  variedad conocida como \u00abcatastr\u00f3fica\u00bb la cual puede aparecer durante el embarazo el puerperio.     en el primer estudio realizamos un estudio multic\u00e9ntrico con seguimiento a lo largo plazo de una amplia serie de pacientes con saf primario, con el fin de determinar su evoluci\u00f3n cl\u00ednica y de identificar los pacientes que desarrollan una \u00abnueva\u00bb enfermedad autoinmune durante el seguimiento. Se incluyeron 128 pacientes con saf primario con un seguimiento medio de 9 a\u00f1os. Once pacientes desarrollaron un les. 6 pacientes un \u00ablupus like disease\u00bb y un paciente una miastenia gravis. Cerca del 90% de los pacientes permanecieron como saf primario despu\u00e9s del seguimiento. despu\u00e9s del an\u00e1lisis multivariado, la presencia de coombs se relacion\u00f3 con el desarrollo de les. Quince pacientes durante el seguimiento fallecieron, fundamentalmente de ventos cardi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antiphospholipid syndrome: expanding the spectrum of autoimmune trhombosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antiphospholipid syndrome: expanding the spectrum of autoimmune trhombosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Puerta Jos\u00e9 Alfredo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricard Cervera Segura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Villardell <\/li>\n<li>Vicent Fonollosa (vocal)<\/li>\n<li>Laura Bertolaccini Mar\u00eda (vocal)<\/li>\n<li>Raimon Snamart\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Puerta Jos\u00e9 Alfredo El s\u00edndrome antifosfolip\u00eddico saf es una enfermedad autoinmune caracterizada pro trombosis venosas o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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