{"id":60753,"date":"2007-04-10T00:00:00","date_gmt":"2007-04-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vias-de-senalizacion-en-enfermedades-prionicas\/"},"modified":"2007-04-10T00:00:00","modified_gmt":"2007-04-10T00:00:00","slug":"vias-de-senalizacion-en-enfermedades-prionicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/vias-de-senalizacion-en-enfermedades-prionicas\/","title":{"rendered":"Vias de se\u00f1alizaci\u00f3n en enfermedades pri\u00f3nicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Agustin Rodr\u00edguez Fernandez <\/strong><\/h2>\n<p>En esta tesis se han utilizado distintas t\u00e9cnicas de biolog\u00eda molecular (inmunohistoqu\u00edmica, western blot, inmunoprecipitaci\u00f3n, taqman pcr, ensayos de actividad enzim\u00e1tica, etc.) Para estudiar la expresi\u00f3n, localizaci\u00f3n celular, etc., De distintos tipos de prote\u00ednas relacionadas con fen\u00f3menos neuropatol\u00f3gicos caracter\u00edsticos de las encefalopat\u00edas espongiformes transmisibles (neurodegeneraci\u00f3n, espongiosis). Estos estudios se han realizado sobre muestras de corteza ftontal post-mortem de casos con enfermedad de creutzfeldt-jakob (ecj) y sobre el cerebro de un modelo murino de la encefalopat\u00eda espongiforme bovina (eeb). En resumen, los resultados obtenidos en los distintos trabajos desarrollados indican alteraciones en algunas v\u00edas de se\u00f1alizaci\u00f3n intracelular (mapks y sus efectores creb y c-fos), el deterioro de la v\u00eda de neurotransmisi\u00f3n glutamat\u00e9rgica mediada por los mglurs, una sensibilizaci\u00f3n de los receptores de adneosina a1rs y un incremento de niveles de aquaporinas cerebrales (aqp1 y aqp4). Los resultados obtenidos muestran la alteraci\u00f3n de ciertos grupos de prote\u00ednas en la corteza formal de ecj y en el cerebro de un modelo murino de la eeb asociado al progreso de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vias de se\u00f1alizaci\u00f3n en enfermedades pri\u00f3nicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vias de se\u00f1alizaci\u00f3n en enfermedades pri\u00f3nicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Agustin Rodr\u00edguez Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Ferrer Abizanda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Grau  Veciana <\/li>\n<li>Teresa Ribalta (vocal)<\/li>\n<li>Aurelio Ariza Fern\u00e1ndez (vocal)<\/li>\n<li>Santiago Ambrosio Viale (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Agustin Rodr\u00edguez Fernandez En esta tesis se han utilizado distintas t\u00e9cnicas de biolog\u00eda molecular (inmunohistoqu\u00edmica, western blot, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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