{"id":60772,"date":"2007-05-10T00:00:00","date_gmt":"2007-05-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-la-funcion-del-factor-de-transcripcion-nfat1-y-de-su-modulacion-farmacologica-por-salicilatos-y-derivados-trifluorometilados\/"},"modified":"2007-05-10T00:00:00","modified_gmt":"2007-05-10T00:00:00","slug":"estudio-de-la-regulacion-de-la-funcion-del-factor-de-transcripcion-nfat1-y-de-su-modulacion-farmacologica-por-salicilatos-y-derivados-trifluorometilados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-inmunologica\/estudio-de-la-regulacion-de-la-funcion-del-factor-de-transcripcion-nfat1-y-de-su-modulacion-farmacologica-por-salicilatos-y-derivados-trifluorometilados\/","title":{"rendered":"Estudio de la regulaci\u00f3n de la funci\u00f3n del factor de transcripci\u00f3n nfat1 y de su modulaci\u00f3n farmacol\u00f3gica por salicilatos y derivados trifluorometilados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica Aceves Tejero <\/strong><\/h2>\n<p>El factor de transcripci\u00f3n nfat es expresado durante la respuesta inmune e inflamatoria. Es blanco farmacol\u00f3gico de los inmunosupresores ciclosporina a y fk506 que revolucionaron el campo del transplante de \u00f3rganos en la d\u00e9cada de los 80. Estos f\u00e1rmacos inhiben la fosfatasa calcineurina que a su vez inhibe la desfosforilaci\u00f3n de la prote\u00edna y el transporte de \u00e9sta al n\u00facleo. Adem\u00e1s, la activaci\u00f3n de la funci\u00f3n de nfat se ve afectada por el uso de f\u00e1rmacos antiinflamatorios como salicilatos y derivados trifluorometilados. Hemos observado que salicilatos inhiben la activaci\u00f3n del factor de transcripci\u00f3n e inhibe el transporte de la prote\u00edna al n\u00facleo, sin embargo, salicilatos y derivados trifluorometilados inhiben la uni\u00f3n de nfat al adn, y por lo tanto la inhibici\u00f3n de la expresi\u00f3n de los genes que regula. Puesto que \u00e1mbos f\u00e1rmacos inhiben la cascada de activaci\u00f3n de nfat a dos niveles diferentes, estudiamos la combinaci\u00f3n de \u00e1mbos para tratar de reducir los efectos indeseados del uso de csa a elevadas dosis y alta concentraci\u00f3n. Conseguimos reducir la dosis de uso actual de csa combin\u00e1ndola junto con una dosis de triflusal utilizada en terap\u00e9tica, de tal manera que se inhib\u00eda la actividad mediada por nfatal igual que cuando se utilizaban dosis consideradas en la actualidad como \u00f3ptimas. Queda por resolver si estos efectos podr\u00edan ser utilizados en cl\u00ednica como alternativa a la terapia inmunosupresora actual.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la regulaci\u00f3n de la funci\u00f3n del factor de transcripci\u00f3n nfat1 y de su modulaci\u00f3n farmacol\u00f3gica por salicilatos y derivados trifluorometilados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la regulaci\u00f3n de la funci\u00f3n del factor de transcripci\u00f3n nfat1 y de su modulaci\u00f3n farmacol\u00f3gica por salicilatos y derivados trifluorometilados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica Aceves Tejero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Rodr\u00edguez M\u00aa Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Garc\u00eda sancho <\/li>\n<li>Manuel Merlos roca (vocal)<\/li>\n<li>Francisco Jos\u00e9 Garc\u00eda c\u00f3zar (vocal)<\/li>\n<li>susana Alemany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica Aceves Tejero El factor de transcripci\u00f3n nfat es expresado durante la respuesta inmune e inflamatoria. Es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2148,12451],"tags":[20824,134235,1108,72658,134234,134236],"class_list":["post-60772","post","type-post","status-publish","format-standard","hentry","category-bioquimica-inmunologica","category-valladolid","tag-francisco-jose-garcia-cozar","tag-garcia-rodriguez-ma-carmen","tag-javier-garcia-sancho","tag-manuel-merlos-roca","tag-monica-aceves-tejero","tag-susana-alemany"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60772"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60772\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}