{"id":60785,"date":"2007-05-10T00:00:00","date_gmt":"2007-05-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-factores-que-inciden-en-la-sa%c2%adntesis-de-microcistina-en-microcystis-aeruginosa-pcc7806-y-diseno-de-un-kit-para-su-cuantificacion\/"},"modified":"2007-05-10T00:00:00","modified_gmt":"2007-05-10T00:00:00","slug":"estudio-de-factores-que-inciden-en-la-sa%c2%adntesis-de-microcistina-en-microcystis-aeruginosa-pcc7806-y-diseno-de-un-kit-para-su-cuantificacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/estudio-de-factores-que-inciden-en-la-sa%c2%adntesis-de-microcistina-en-microcystis-aeruginosa-pcc7806-y-diseno-de-un-kit-para-su-cuantificacion\/","title":{"rendered":"Estudio de factores que inciden en la s\u00edntesis de microcistina en microcystis aeruginosa pcc7806 y dise\u00f1o de \u00fan kit para su cuantificaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emma Sevilla Miguel <\/strong><\/h2>\n<p>Las cianobacterias producen en determinadas condiciones toxinas que provocan grandes problemas sanitarios y medioambientales.En las aguas dulces, la presencia de cianotoxinas se esta convirtiendo en un problema creciente, debido a la imparable eutrofizaci\u00f3nde los acu\u00edferos. Las toxinas producidas son fundamentalmente hepatot\u00f3xicas y neurot\u00f3xicas, y una de las cepas m\u00e1s virulentas esmicrocystis aeruginosa, que produce la hepatotoxina microcistina.Las microcistinas son heptap\u00e9ptidos c\u00edclicos constituidos por amino\u00e1cidos proteicos y no proteicos(-d-ala-x-d_measp-z-adda-d-glu-mdha-). Existen m\u00e1s de 70 variantes diferentes de microcistinas en funci\u00f3n de dosamino\u00e1cidos variables que se denominan x y z. La variante m\u00e1s habitual es la microcistina lr que contiene l-leucina y l?Arginina .Las microcistinas ejercen su efecto t\u00f3xico inhibiendo espec\u00edficamente a serin-treonin fosfatasas, en concreto a la protein fosfatasa 1(pp1) y protein fosfatasa 2a (pp2a). Estas toxinas entran en el h\u00edgado a trav\u00e9s de receptores espec\u00edficos de \u00e1cidos biliares y comoconsecuencia de la inactivaci\u00f3n de las protein fosfatasas, se produce una hiperfosforilaci\u00f3n del citoesqueleto de los hepatocitos, queconlleva la destrucci\u00f3n del hepatocito.La s\u00edntesis de microcistina es una s\u00edntesis enzim\u00e1tica no ribosomal, llevada a cabo por p\u00e9ptido sintetasas y polic\u00e9tido sintasas queest\u00e1n codificados en un cluster g\u00e9nico que en m. Aeruginosa pcc 7806 se denomin\u00f3 oper\u00f3n mcy (tillett et al., 2000). Existecontroversia en el efecto de los distintos factores ambientales y nutricionales sobre la producci\u00f3n de microcistina. En la literaturaaparecen una gran variedad de resultados dentro de los cuales incluso encontramos resultados contradictorios, como es el caso delefecto del hierro (lukac and aegerter, 1993; utkilen and gjolme, 1995; lyck, 1996). Adem\u00e1s el papel de la microcistina esdesconocido tanto en el interior como en el exterior celular (kaebemick and neilan, 2001). actualmente<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de factores que inciden en la s\u00edntesis de microcistina en microcystis aeruginosa pcc7806 y dise\u00f1o de \u00fan kit para su cuantificaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de factores que inciden en la s\u00edntesis de microcistina en microcystis aeruginosa pcc7806 y dise\u00f1o de \u00fan kit para su cuantificaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emma Sevilla Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M.Luisa Peato S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ana Came\u00e1n fern\u00e1ndez <\/li>\n<li> Inda aramend\u00eda Luis \u00e1ngel (vocal)<\/li>\n<li>marina Aboal sanjurjo (vocal)<\/li>\n<li>Luis Mata vallesp\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emma Sevilla Miguel Las cianobacterias producen en determinadas condiciones toxinas que provocan grandes problemas sanitarios y medioambientales.En [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2148,115,3178,13610],"tags":[67975,134268,134270,134271,134269,30123],"class_list":["post-60785","post","type-post","status-publish","format-standard","hentry","category-bioquimica-inmunologica","category-bioquimica-molecular","category-proteinas","category-zaragoza","tag-ana-camean-fernandez","tag-emma-sevilla-miguel","tag-inda-aramendia-luis-angel","tag-luis-mata-vallespin","tag-m-luisa-peato-sanchez","tag-marina-aboal-sanjurjo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60785"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60785\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}