{"id":60792,"date":"2007-05-10T00:00:00","date_gmt":"2007-05-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-regulacion-de-la-homeostasis-del-zinc-por-el-activador-transcripcional-zafa-es-esencial-para-la-virulencia-de-aspergillus-fumigatus\/"},"modified":"2007-05-10T00:00:00","modified_gmt":"2007-05-10T00:00:00","slug":"la-regulacion-de-la-homeostasis-del-zinc-por-el-activador-transcripcional-zafa-es-esencial-para-la-virulencia-de-aspergillus-fumigatus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-vegetal\/la-regulacion-de-la-homeostasis-del-zinc-por-el-activador-transcripcional-zafa-es-esencial-para-la-virulencia-de-aspergillus-fumigatus\/","title":{"rendered":"La regulaci\u00f3n de la homeostasis del zinc por el activador transcripcional zafa es esencial para la virulencia de aspergillus fumigatus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel \u00e1ngel Moreno Hidalgo <\/strong><\/h2>\n<p>Nosotros hemos demostrado previamente que aspergillus fumigatus es capaz de crecer en medios limitantes en zinc y que esta habilidad es regulada a nivel transcripcional por la disponibilidad de zinc y el ph ambiental. Cuando a. Fumigatus se comporta como un pat\u00f3geno, debe ser capaz de captar zinc del ambiente limitante en zinc que representan los tejidos del hospedador. De acuerdo con esto, la regulaci\u00f3n de la homeostasis del zinc por alg\u00fan factor de transcripci\u00f3n que responda a la concentraci\u00f3n de zinc ambiental en a. Fumigatus debe ser esencial para el crecimiento del hongo sobre los tejidos de un hospedador inmunocomprometido y, por tanto, para su patogenicidad. Nosotros proporcionamos ahora evidencias del papel del gen zafa en la regulaci\u00f3n de la homeostasis del zinc y su relevancia en la virulencia de a. Fumigatus. As\u00ed, se observa que: (i) zafa puede remplazar funcionalmente al gen zap1 de saccharomyces cerevisiae que codifica para el factor de transcripci\u00f3n sensor de zinc zap1; (ii) la expresi\u00f3n del mismo zafa se induce en medios limitantes en zinc y se reprime por zinc; (iii) la deleci\u00f3n de zafa reduce la germinaci\u00f3n y la capacidad de crecimiento de a. Fumigatus en medios limitantes en zinc; (iv) la deleci\u00f3n de zafa tambi\u00e9n elimina la virulencia de a. Fumigatus en un modelo murino de aspergilosis invasiva. De acuerdo con lo anterior, se concluye que zafa es un factor de transcripci\u00f3n sensor de zinc que representa un atributo esencial para la patogenicidad de a. Fumigatus. Por tanto, zafa podr\u00eda constituir una nueva diana para el desarrollo de un nuevo agente antif\u00fangico contra aspergillus, ya que no existen ort\u00f3logos de zafa en mam\u00edferos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La regulaci\u00f3n de la homeostasis del zinc por el activador transcripcional zafa es esencial para la virulencia de aspergillus fumigatus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La regulaci\u00f3n de la homeostasis del zinc por el activador transcripcional zafa es esencial para la virulencia de aspergillus fumigatus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel \u00e1ngel Moreno Hidalgo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Calera Abad<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jean paul Latg\u00e9 <\/li>\n<li>joaqu\u00edn Ari\u00f1o carmona (vocal)<\/li>\n<li>Miguel \u00e1ngel Pe\u00f1alva soto (vocal)<\/li>\n<li>yolanda Sanchez martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel \u00e1ngel Moreno Hidalgo Nosotros hemos demostrado previamente que aspergillus fumigatus es capaz de crecer en medios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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