{"id":60794,"date":"2007-05-10T00:00:00","date_gmt":"2007-05-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celula-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-cancera%c2%adgenas-en-un-modelo-de-raton-para-maf-b\/"},"modified":"2007-05-10T00:00:00","modified_gmt":"2007-05-10T00:00:00","slug":"celula-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-cancera%c2%adgenas-en-un-modelo-de-raton-para-maf-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/celula-stem-y-cancer-humano-el-programa-genetico-de-las-celulas-stem-cancera%c2%adgenas-en-un-modelo-de-raton-para-maf-b\/","title":{"rendered":"C\u00e9lula stem y c\u00e1ncer humano: el programa gen\u00e9tico de las c\u00e9lulas stem cancer\u00edgenas en un modelo de rat\u00f3n para maf-b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Vicente Due\u00f1as <\/strong><\/h2>\n<p>Con el t\u00e9rmino mieloma m\u00faltiple (mm) se denomina al s\u00edndrome cl\u00ednico de la neoplasia conocida como mieloma de c\u00e9lulas plasm\u00e1ticas. Se caracteriza por la secreci\u00f3n anormal de inmunoglobulina monoclonal, lesiones osteol\u00edticas y anemia. en la actualidad, el mm es una neoplasia incurable, a pesar de la quimioterapia y los transplantes, con una supervivencia media de 6 a\u00f1os. El desarrollo de modelos animales apropiados para estudiar la biolog\u00eda del mm nos ayudar\u00eda indudablemente a clarificar los mecanismos que tienen lugar en el desarrollo de la enfermedad y a dise\u00f1ar terapias efectivas. Los modelos transg\u00e9nicos actuales se han generado partiendo de la hip\u00f3tesis de que el mm se origina en una c\u00e9lula b o en una c\u00e9lula plasm\u00e1tica. \u00e9stos reproducen s\u00f3lo alguna caracter\u00edstica cl\u00ednica del mm y no toda su sintomatolog\u00eda. Adem\u00e1s, el transg\u00e9n elegido no se corresponde con la alteraci\u00f3n gen\u00e9tica principal que va a dar lugar al mm. una idea en la biolog\u00eda del c\u00e1ncer que cada vez toma m\u00e1s fuerza, es la de que los tumores se generan y crecen como resultado de la formaci\u00f3n de las c\u00e9lulas stem cancer\u00edgenas que constituyen solo una minor\u00eda de las c\u00e9lulas que forman parte del tumor pero que son cr\u00edticas para su propagaci\u00f3n. Ya que las c\u00e9lulas stem y las c\u00e9lulas stem cancer\u00edgenas comparten muchas caracter\u00edsticas, parece tener sentido que el c\u00e1ncer humano derive de \u00e9stas. con el presente trabajo apoyamos la idea de que el mm es tambi\u00e9n una enfermedad de c\u00e9lula stem. Para ello, se ha dise\u00f1ado un modelo animal basado en esta hip\u00f3tesis que consigue reproducir la patolog\u00eda humana: hemos limitado la expresi\u00f3n del oncog\u00e9n mafb (implicado en un 5% de los mm humanos) a las c\u00e9lulas stem del sistema hematopoy\u00e9tico utilizando transg\u00e9nesis convencional y hemos conseguido reproducir la enfermedad humana bas\u00e1ndonos en los mismos criterios diagn\u00f3sticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>C\u00e9lula stem y c\u00e1ncer humano: el programa gen\u00e9tico de las c\u00e9lulas stem cancer\u00edgenas en un modelo de rat\u00f3n para maf-b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 C\u00e9lula stem y c\u00e1ncer humano: el programa gen\u00e9tico de las c\u00e9lulas stem cancer\u00edgenas en un modelo de rat\u00f3n para maf-b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Vicente Due\u00f1as <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Javier S\u00e1nchez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Piris pinilla <\/li>\n<li>lLuis Montoliu jose (vocal)<\/li>\n<li>Rafael Jimenez fern\u00e1ndez (vocal)<\/li>\n<li>Miguel Torres sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Vicente Due\u00f1as Con el t\u00e9rmino mieloma m\u00faltiple (mm) se denomina al s\u00edndrome cl\u00ednico de la neoplasia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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