{"id":60807,"date":"2007-08-10T00:00:00","date_gmt":"2007-08-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-antiproliferativos-del-gen-supresor-rb-en-cancer-de-pancreas-humano\/"},"modified":"2007-08-10T00:00:00","modified_gmt":"2007-08-10T00:00:00","slug":"efectos-antiproliferativos-del-gen-supresor-rb-en-cancer-de-pancreas-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/efectos-antiproliferativos-del-gen-supresor-rb-en-cancer-de-pancreas-humano\/","title":{"rendered":"Efectos antiproliferativos del gen supresor rb en cancer de pancreas humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josep Mar\u00eda Roig Camacho <\/strong><\/h2>\n<p>El supresor de tumores rb est\u00e1 involucrado directamente en el control del ciclo celular i apoptosis. Alteraciones en la ruta de rb son habituales en el c\u00e1ncer de p\u00e1ncreas. Por ello, el c\u00e1ncer de p\u00e1ncreas es un modelo resistente a la sobreexpresi\u00f3n de la prote\u00edna rb como tratamiento antitumoral, i a su vez un modelo ideal para determinar la capacidad antiproliferativa de formas alternativas de la prote\u00edna rb con un mayor efecto antitumoral asociado. En este estudio, hemos querido evaluar la  capacidad antiproliferativa de rb94, prote\u00edna rb truncada en los 112 primeros amino\u00e1cidos del extremo n-terminal. Hemos determinado los efectos antiproliferativos en un panel de l\u00edneas tumorales pancre\u00e1ticas tanto a nivel in vitro como in vivo. A nivel in vitro se han observado los efectos de rb94 en la progresi\u00f3n de ciclo celular  y la inducci\u00f3n de apoptosis. Posteriormente, se han determinado las fases del ciclo celular en el que rb94 ejerce el efecto supresor. Se han estudiado las posibles v\u00edas utilizadas por rb94 para realizar sus efectos i tambi\u00e9n hemos querido potencias el efecto de las drogas utilizadas habitualmente como antitumorales, se el caso del cisplatino o la gemcitabina, con la sobreexpresi\u00f3n de rb94. Finalmente tambi\u00e9n hemos querido mejorar la eficiencia i la especificidad del vector utilizado, mediado por un redireccionamiento con reactivo bidifuncional a receptores de fgf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos antiproliferativos del gen supresor rb en cancer de pancreas humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos antiproliferativos del gen supresor rb en cancer de pancreas humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josep Mar\u00eda Roig Camacho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adela Mazo Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Casado merediz <\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<li>cristina Fillat (vocal)<\/li>\n<li>Manuel Cascall\u00f3 piqueras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josep Mar\u00eda Roig Camacho El supresor de tumores rb est\u00e1 involucrado directamente en el control del ciclo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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