{"id":60875,"date":"2018-03-09T22:48:44","date_gmt":"2018-03-09T22:48:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hexoquinasa-2-un-enzima-metabolico-con-funciones-reguladoras\/"},"modified":"2018-03-09T22:48:44","modified_gmt":"2018-03-09T22:48:44","slug":"hexoquinasa-2-un-enzima-metabolico-con-funciones-reguladoras","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oviedo\/hexoquinasa-2-un-enzima-metabolico-con-funciones-reguladoras\/","title":{"rendered":"Hexoquinasa 2, un enzima metabolico con funciones reguladoras"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Riera Sanchez <\/strong><\/h2>\n<p>Dos de las prote\u00ednas m\u00e1s importantes implicadas en la represi\u00f3n por glucosa en saccharomyces cerevisiae son mig1 y hxk2. El mecanismo a trav\u00e9s del que opera la prote\u00edna hxk2 no se conoce con precisi\u00f3n, pero la parte dependiente del represor transcripcional mig1 en la regulaci\u00f3n de genes como suc2 (que codifica para la invertasa) se ha estudiado con gran detalle (1,2). En concreto, la prote\u00edna mig1 resulta fundamental para reprimir la expresi\u00f3n del gen cuando la levadura crece en presencia de glucosa, condiciones en las que el microorganismo no precisa la presencia del enzima invertasa (1). Cuando la concentraci\u00f3n del monosac\u00e1rido en el medio disminuye, suc2 se desreprime. Aunque mig1 resulta crucial para la regulaci\u00f3n del gen, realiza su papel formando parte de un complejo represor que integra muchas otras prote\u00ednas. A\u00fan no se conoce el papel concreto de la hexoquinasa 2 en la regulaci\u00f3n de suc2 ni tampoco el del complejo snf1, sin embargo, se sabe que  la ausencia de estas prote\u00ednas tiene un profundo impacto en la represi\u00f3n del gen. el trabajo se enfoc\u00f3 en torno a dos objetivos principales, por un lado al estudio de los mecanismo de se\u00f1alizaci\u00f3n por glucosa de saccharomyces cerevisiae (tanto en lo que se refiere a la represi\u00f3n como a la inducci\u00f3n g\u00e9nica mediada por este monosac\u00e1rido) utilizando como gen modelo suc2. Por otro, a la extrapolaci\u00f3n de los resultados obtenidos en levaduras a la se\u00f1alizaci\u00f3n por glucosa en las c\u00e9lulas de animales superiores a fin de establecer puntos de convergencia en las rutas de ambos tipos de organismos, puntos que permitir\u00edan abrir nuevas v\u00edas para identificar procesos de regulaci\u00f3n por la se\u00f1al glucosa a\u00fan no establecidos en mam\u00edferos. con estos fines, analizamos en la levadura el papel de la fracci\u00f3n nuclear de la prote\u00edna hxk2 en la represi\u00f3n por glucosa del gen suc2. Para ello, estudiamos la relaci\u00f3n de la hxk2 con mig1 y las prote\u00ednas del complejo snf1. Adem\u00e1s, analizamos la funcionalid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hexoquinasa 2, un enzima metabolico con funciones reguladoras<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hexoquinasa 2, un enzima metabolico con funciones reguladoras <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Riera Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Moreno Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan a Mar\u00eda Sempere caudec <\/li>\n<li>joaqu\u00edn Ari\u00f1o carmona (vocal)<\/li>\n<li>jurgen Heinisch (vocal)<\/li>\n<li>francisca Randez gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Riera Sanchez Dos de las prote\u00ednas m\u00e1s importantes implicadas en la represi\u00f3n por glucosa en saccharomyces [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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