{"id":6089,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/activacion-temprana-linfocitaria-en-lupus-eritematoso-sistemico-y-artritis-reumatoide\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"activacion-temprana-linfocitaria-en-lupus-eritematoso-sistemico-y-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/activacion-temprana-linfocitaria-en-lupus-eritematoso-sistemico-y-artritis-reumatoide\/","title":{"rendered":"Activacion temprana linfocitaria en lupus eritematoso sistemico y artritis reumatoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Benjamin Fernandez Gutierrez <\/strong><\/h2>\n<p>El lupus eritematoso sistemico (les) y la artritis reumatoide (ar) son dos enfermedades de naturaleza autoinmune caracterizadas por alteraciones en la activacion y funcionalidad de sus linfocitos (linfs) b y t, pero con una expresividad clinica muy diferente. El estudio de la activacion temprana basado en la deteccion de dos antigenos de membrana, cd23 (linfs b) y cd69(linfs t), es distinta en estas enfermedades.  en el les, los linfs b parecen responder de manera normal a estimulos directos (activacion con il-4), pero responden defectuosamente a estimulos transmitidos por linfs t activados. Por otra parte, los linfs t en esta patolog\u00eda responden defectuosamente a todos los estimulso empleados (anti-cd3, pma), por lo que un defecto intrinseco de activacion del linf t parece ser inherente a esta patolog\u00eda.  en la ar, los linfs b hiperresponden a se\u00f1ales tanto directas (il-4) como transmitidas por linfs t, sin embargo el estimulo con pma iguala la activacion de los linfs b de ar con respecto a los controles por lo que una preactivacion de la pkc de los linfs b de ar parece desprenderse de estos hallazgos. Los linfs t de ar se activan defectuosamente a traves de cd3 pero no asi a traves de pkc.  en el organo diana de la ar (articulacion), los linfs b presentan una activacion temprana disminuida y los linfs t una activacion temprana muy incrementada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activacion temprana linfocitaria en lupus eritematoso sistemico y artritis reumatoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activacion temprana linfocitaria en lupus eritematoso sistemico y artritis reumatoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Benjamin Fernandez Gutierrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Jover Jover Juan  Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Fernandez Cruz <\/li>\n<li>Baltasar Orejas Gonzalez (vocal)<\/li>\n<li>Jes\u00fas Millan Nu\u00f1ez Cortes (vocal)<\/li>\n<li> De La Morena Julio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benjamin Fernandez Gutierrez El lupus eritematoso sistemico (les) y la artritis reumatoide (ar) son dos enfermedades de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,877],"tags":[723,23198,23197,23199,1552,22772],"class_list":["post-6089","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-reumatologia","tag-arturo-fernandez-cruz","tag-baltasar-orejas-gonzalez","tag-benjamin-fernandez-gutierrez","tag-de-la-morena-julio","tag-jesus-millan-nunez-cortes","tag-jover-jover-juan-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/6089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=6089"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/6089\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=6089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=6089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=6089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}