{"id":60947,"date":"2018-03-09T22:48:47","date_gmt":"2018-03-09T22:48:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-moleculares-de-la-tolerancia-central\/"},"modified":"2018-03-09T22:48:47","modified_gmt":"2018-03-09T22:48:47","slug":"aspectos-moleculares-de-la-tolerancia-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/aspectos-moleculares-de-la-tolerancia-central\/","title":{"rendered":"Aspectos moleculares de la tolerancia central"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lidia Sabater Baudet <\/strong><\/h2>\n<p>Las especificidades del repertorio t se generan mediante la recombinaci\u00f3n de segmentos g\u00e9nicos al azar por lo que un porcentaje de c\u00e9lulas son autorreactivas. La tolerancia del repertorio t hacia las mol\u00e9culas propias se consigue en primera instancia mediante la selecci\u00f3n t\u00edmica. El fen\u00f3meno de la expresi\u00f3n promiscua consiste en la expresi\u00f3n intrat\u00edmica de autoant\u00edgenos perif\u00e9ricos propios de otros tejidos. Las c\u00e9lulas medulares t\u00edmicas, principalmente, ser\u00edan las c\u00e9lulas encargadas de expresar estos autoant\u00edgenos. El gen aire es un factor de transcripci\u00f3n que se expresa principalmente en las c\u00e9lulas epiteliales medulares t\u00edmicas y que es responsable de regular la expresi\u00f3n promiscua en el timo. Este gen codifica para una prote\u00edna con dedos de zinc que ejerce su funci\u00f3n regulando el nivel de transcripci\u00f3n de los genes expresados promiscuamente, aunque todav\u00eda no est\u00e1 bien establecido el modelo de actuaci\u00f3n. Otro nivel de regulaci\u00f3n de la expresi\u00f3n g\u00e9nica se dar\u00eda a nivel post-transcr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos moleculares de la tolerancia central<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos moleculares de la tolerancia central <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lidia Sabater Baudet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Pujol Borrell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Dolores Jaraquemada P\u00e9rez De Guzm\u00e1n <\/li>\n<li>Conchi Mora Giral (vocal)<\/li>\n<li>Joan Verdaguer Autonell (vocal)<\/li>\n<li>Luis Santamaria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lidia Sabater Baudet Las especificidades del repertorio t se generan mediante la recombinaci\u00f3n de segmentos g\u00e9nicos al [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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