{"id":60948,"date":"2018-03-09T22:48:47","date_gmt":"2018-03-09T22:48:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptotic-and-antiapoptotic-mechanisms-in-neurons-and-glial-cells-after-damage-to-the-immature-brain\/"},"modified":"2018-03-09T22:48:47","modified_gmt":"2018-03-09T22:48:47","slug":"apoptotic-and-antiapoptotic-mechanisms-in-neurons-and-glial-cells-after-damage-to-the-immature-brain","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/apoptotic-and-antiapoptotic-mechanisms-in-neurons-and-glial-cells-after-damage-to-the-immature-brain\/","title":{"rendered":"Apoptotic and antiapoptotic mechanisms in neurons and glial cells after damage to the immature brain"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Villapol Salgado <\/strong><\/h2>\n<p>Although it is well established that apoptotic mechanisms play a central role in neuronal death after different types of cns damage, little is known about the activation of apoptotic pathways in glial cells which have been postulated to be important for the termination of the glial response. It is remarkable that the classically defined main executioner of programmed cell death, caspase-3, has recently been attributed a non-apoptotic role, participating in cellular events including cell proliferation, cell cycle regulation, or cellular differentiation. Accordingly, the general aim of this thesis was to analyze the putative role of the classic apoptotic and anti-apoptotic pathways after acute excitotoxic damage to the immature rat brain. For this purpose, a well-characterized in vivo model of excitotoxicity was used, where damage was induced by the intracortical injection of n-methyl-d-asparate (nmda) in postnatal day 9 rats. Cell death, apoptotic and anti-apoptotic proteins were analyzed at different survival times after the lesion by enzymatic assays and double immunofluorescence for confocal microscope analysis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apoptotic and antiapoptotic mechanisms in neurons and glial cells after damage to the immature brain<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apoptotic and antiapoptotic mechanisms in neurons and glial cells after damage to the immature brain <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Villapol Salgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Laia Acarin P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Rodriguez Alvarez <\/li>\n<li>Cristina Munoz-pinedo (vocal)<\/li>\n<li>Val\u00e9rie Petegnief (vocal)<\/li>\n<li>Ann Chowen Julie (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Villapol Salgado Although it is well established that apoptotic mechanisms play a central role in neuronal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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