{"id":60954,"date":"2018-03-09T22:48:47","date_gmt":"2018-03-09T22:48:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-capacidad-neurogenica-de-los-precursores-neurales-de-los-vertebrados-durante-el-ciclo-celular\/"},"modified":"2018-03-09T22:48:47","modified_gmt":"2018-03-09T22:48:47","slug":"regulacion-de-la-capacidad-neurogenica-de-los-precursores-neurales-de-los-vertebrados-durante-el-ciclo-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/regulacion-de-la-capacidad-neurogenica-de-los-precursores-neurales-de-los-vertebrados-durante-el-ciclo-celular\/","title":{"rendered":"Regulacion de la capacidad neurogenica de los precursores neurales de los vertebrados durante el ciclo celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elsa Cisneros Ni\u00f1o <\/strong><\/h2>\n<p>La neurog\u00e9nesis es un proceso controlado a trav\u00e9s de las se\u00f1ales de inhibici\u00f3n lateral mediadas por el receptor notch y su ligando delta. La capacidad de los precursores neurales del embri\u00f3n de pollo e4 para expresar los genes neurog\u00e9nicos notch1 y delta 1 se reduce durante la fase de s\u00edntesis, lo que sugiere que el potencial de estas c\u00e9lulas para activar la inhibici\u00f3n lateral var\u00eda durante el ciclo celular. En el presente trabajo, se demuestra que la disminuci\u00f3n de los niveles de notch1 y delta 1 durante la fase de s\u00edntesis sucede tambi\u00e9n en los precursores neurales de etapas posteriores del desarrollo en el pollo y en otros vertebrados, como el rat\u00f3n. Asimismo, la expresi\u00f3n de ifng, un gen regulador de la funci\u00f3n de notch, y de los genes efectores de notch, hairy1\/hes1 y hes5, disminuye en los precursores neurales de pollo y de rat\u00f3n durante la fase de s\u00edntesis, lo que demuestra que el fen\u00f3meno de inhibici\u00f3n lateral se restringe a una ventana del ciclo celular comprendida por las fases g2\/mitosis\/g1. A pesar de que la activaci\u00f3n de notch est\u00e1 reducida durante la fase de s\u00edntesis, la expresi\u00f3n de delta1 no aumenta durante esta fase del ciclo celular y, adem\u00e1s, los genes proneurales de determinaci\u00f3n ngn2 y npn1 disminuyen sus niveles. Este conjunto de observaciones indicar\u00edan que el potencial neurog\u00e9nico se encuentra reducido durante la fase de s\u00edntesis. Finalmente, este trabajo demuestra que las variaciones observadas en la exp5resi\u00f3n de notch1 y delta1 durante el ciclo celular se deben a una disminuci\u00f3n en la estabilidad de sus transcritos durante la fase de s\u00edntesis. Estos resultados aportar evidencias de que el potencial neurog\u00e9nico de los precursores neurales de los vertebrados est\u00e1 coordinado con el ciclo celular, lo que probablemente facilita que la diferenciaci\u00f3n neuronal no suceda antes de la mitosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la capacidad neurogenica de los precursores neurales de los vertebrados durante el ciclo celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la capacidad neurogenica de los precursores neurales de los vertebrados durante el ciclo celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elsa Cisneros Ni\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Frade L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Gir\u00e1ldez orgaz <\/li>\n<li>paola Bovolenta nicolao (vocal)<\/li>\n<li>Francisco Tejedor rescalvo (vocal)<\/li>\n<li>Mar\u00eda  angeles Arevalo arevalo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elsa Cisneros Ni\u00f1o La neurog\u00e9nesis es un proceso controlado a trav\u00e9s de las se\u00f1ales de inhibici\u00f3n lateral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,35],"tags":[134645,12616,4355,29768,122296,29565],"class_list":["post-60954","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-de-la-vida","tag-elsa-cisneros-nino","tag-fernando-giraldez-orgaz","tag-francisco-tejedor-rescalvo","tag-jose-maria-frade-lopez","tag-maria-angeles-arevalo-arevalo","tag-paola-bovolenta-nicolao"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=60954"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/60954\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=60954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=60954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=60954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}