{"id":60982,"date":"2018-03-09T22:48:47","date_gmt":"2018-03-09T22:48:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ficotoxinas-marinas-estudio-de-citotoxicidad-en-distintos-modelos-celulares\/"},"modified":"2018-03-09T22:48:47","modified_gmt":"2018-03-09T22:48:47","slug":"ficotoxinas-marinas-estudio-de-citotoxicidad-en-distintos-modelos-celulares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/ficotoxinas-marinas-estudio-de-citotoxicidad-en-distintos-modelos-celulares\/","title":{"rendered":"Ficotoxinas marinas: estudio de citotoxicidad en distintos modelos celulares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Isabel Rodriguez Ares <\/strong><\/h2>\n<p>Las proliferaciones microalgales son fen\u00f3menos que ocurren de forma natural dentro de la din\u00e1mica del ecosistema marino y, por lo general, son beneficiosas para la acuicultura y el desarrollo de recursos pesqueros. Sin embargo, cuando las especies que proliferan son t\u00f3xicas suponen un grave riesgo para la salud p\u00fablica, puesto que, las ficotoxinas que producen son responsables de m\u00faltiples intoxicaciones en el hombre al que llegan a trav\u00e9s de vectores tales como moluscos bivalvos o peces herb\u00edvoros. esta tesis doctoral caracteriza la respuesta t\u00f3xica inducida por ficotoxinas relacionadas con des\u00f3rdenes de tipo gastrointestinal y\/o neurol\u00f3gico, sobre el citoesqueleto de dos modelos celulares, uno neuronal y otro intestinal. Utilizando t\u00e9cnicas de citometr\u00eda de barrido l\u00e1ser y microscop\u00eda confocal, se investig\u00f3 tanto cuantitativa como cualitativamente la capacidad de estos compuestos para alterar la actina, as\u00ed como el papel del i\u00f3n calcio en estos efectos y las posibles consecuencias morfol\u00f3gicas. Las conclusiones m\u00e1s relevantes de este trabjo han sido las siguientes: &#8211; existe una relaci\u00f3n entre la estructura y la actividad citot\u00f3xica de las pectenotoxinas en la que la presencia de un anillo lact\u00f3nico intacto constituye un factor esencial para que puedan despolimerizar la actina. &#8211; el metil ocadato es un compuesto bioactivo de menor potencial t\u00f3xico que el \u00e1cido ocadaico pero con una acci\u00f3n de caracter\u00edsticas similares sobre la actina polim\u00e9rica y la morfolog\u00eda. &#8211; el mecanismo citot\u00f3xico de la maitotoxina implica la desintegraci\u00f3n del sistema de microfilamentos, sin cambios cuantitativos en la actina globular. Esta acci\u00f3n se produce a trav\u00e9s de una ruta dependiente en su mayor\u00eda de calcio extracelular, ejerciendo un efecto m\u00e1s intenso en el modelo celular neuronal. &#8211; la palitoxina y su an\u00e1logo, la ostreocina-d, tienen efectos muy similares sobre el citoesqueleto y la citomorfolog\u00eda, aunque muestran diferente comportamiento en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ficotoxinas marinas: estudio de citotoxicidad en distintos modelos celulares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ficotoxinas marinas: estudio de citotoxicidad en distintos modelos celulares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Isabel Rodriguez Ares <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis M Botana L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Ramos Mart\u00ednez Juan  Ignacio <\/li>\n<li>Juan Blanco P\u00e9rez (vocal)<\/li>\n<li> Vieites Baptista De Sousa Juan  Manuel (vocal)<\/li>\n<li>Francisco Orallo Cambeiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Isabel Rodriguez Ares Las proliferaciones microalgales son fen\u00f3menos que ocurren de forma natural dentro de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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