{"id":61008,"date":"2018-03-09T22:48:51","date_gmt":"2018-03-09T22:48:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-mam-descripcion-de-factores-predictivos-y-pronosticos-de-respuesta-a-quimioterapia-neoadyuvante\/"},"modified":"2018-03-09T22:48:51","modified_gmt":"2018-03-09T22:48:51","slug":"cancer-de-mam-descripcion-de-factores-predictivos-y-pronosticos-de-respuesta-a-quimioterapia-neoadyuvante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cancer-de-mam-descripcion-de-factores-predictivos-y-pronosticos-de-respuesta-a-quimioterapia-neoadyuvante\/","title":{"rendered":"Cancer de mam. descripcion de factores predictivos y pronosticos de respuesta a quimioterapia neoadyuvante"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Manel Gasent Blesa <\/strong><\/h2>\n<p>El tratamiento neoadyuvante del c\u00e1ncer de mama   es hoy en d\u00eda una pr\u00e1ctica habitual en nuestros hospitales y constituye el escenario ideal de medici\u00f3n de eficacia dependiente de la quimiosensibilidad del propio tumor. Esto ha permitido identificar nuevos f\u00e1rmacos m\u00e1s activos y la posibilidad de medir \u00aba priori\u00bb las particularidades moleculares de los tumores que mejor consiguen predecir la respuesta en un corto periodo de tiempo. El empleo de tecnolog\u00eda microarray permite el estudio de cientos-miles de genes con un ahorro importante de tiempo y tejido, am\u00e9n de una mayor reproducibilidad y homogeneidad de resultados. Con dicha t\u00e9cnica, el autor del presente trabajo pretende estudiar en una muestra de 21 c\u00e1nceres de mama sometidos a tratamiento neoadyuvante con antraciclinas y taxanos secuenciales, la relaci\u00f3n existente entre 22 genes relevantes en v\u00edas celulares de estimulo del crecimiento, neoangiog\u00e9nesis, inhibici\u00f3n de apoptosis y reparaci\u00f3n de adn y la posibilidad de respuesta a la quimioterapia. La expresi\u00f3n de dichos genes puede ser examinada en laboratorios convencionales de anatom\u00eda patol\u00f3gica con las t\u00e9cnicas habituales de inmunohistoqu\u00edmica. Se analiza:  \u00abrelaci\u00f3n entre expresi\u00f3n de cada uno de los marcadores seleccionados y datos cl\u00ednico-patol\u00f3gicos con valor pron\u00f3stico (tama\u00f1o tumoral, afectaci\u00f3n qanglionar, estadio y grado histol\u00f3qico) \u00abmarcadores relacionados con la respuesta completa patol\u00f3gica a la quimioterapia neoadyuvante \u00abvariaci\u00f3n en la expresi\u00f3n de los marcadores seleccionados antes y despu\u00e9s del tratamiento quimioter\u00e1pico y relaci\u00f3n de los cambios objetivados con el tipo de respuesta obtenida \u00abpotencial aplicaci\u00f3n de los resultados obtenidos a la pr\u00e1ctica  cl\u00ednica si bien la muestra analizada carece de potencia estad\u00edstica por el escaso n\u00famero de tumores analizados,    permite demostrar la aplicabilidad de la t\u00e9cnica y su gran potencial generador de hip\u00f3tesis de trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cancer de mam. descripcion de factores predictivos y pronosticos de respuesta a quimioterapia neoadyuvante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cancer de mam. descripcion de factores predictivos y pronosticos de respuesta a quimioterapia neoadyuvante <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Manel Gasent Blesa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Alberola candel <\/li>\n<li>margarita Sanchez boato (vocal)<\/li>\n<li>eduardo De la morena valenzuela (vocal)<\/li>\n<li>Carlos Solano bercet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Manel Gasent Blesa El tratamiento neoadyuvante del c\u00e1ncer de mama es hoy en d\u00eda una pr\u00e1ctica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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