{"id":61017,"date":"2018-03-09T22:48:51","date_gmt":"2018-03-09T22:48:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/fisiopatologa%c2%ada-de-las-manifestaciones-neurologicas-del-deficit-de-hipoxantina-guanina-forroribosiltransferasa-hprt-implicaciones-de-las-purinas-como-neuromoduladores\/"},"modified":"2018-03-09T22:48:51","modified_gmt":"2018-03-09T22:48:51","slug":"fisiopatologa%c2%ada-de-las-manifestaciones-neurologicas-del-deficit-de-hipoxantina-guanina-forroribosiltransferasa-hprt-implicaciones-de-las-purinas-como-neuromoduladores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/fisiopatologa%c2%ada-de-las-manifestaciones-neurologicas-del-deficit-de-hipoxantina-guanina-forroribosiltransferasa-hprt-implicaciones-de-las-purinas-como-neuromoduladores\/","title":{"rendered":"Fisiopatolog\u00eda de las manifestaciones neurol\u00f3gicas del d\u00e9ficit de hipoxantina-guanina forroribosiltransferasa (hprt). implicaciones de las purinas como neuromoduladores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Prior De Castro <\/strong><\/h2>\n<p>La deficiencia de hprt es un grave trastorno del metabolismo de las purinas. Una deficiencia enzim\u00e1tica completa ocasiona el s\u00edndrome de lesch-nyhan (sln). Cl\u00ednicamente se caracteriza por hiperuricemia y alteraciones motoras y del comportamiento t\u00edpicas de disfunci\u00f3n del ganglio basal. La fisiopatolog\u00eda de estas manifestaciones neurol\u00f3gicas es desconocida. planteamos la hip\u00f3tesis de que la funci\u00f3n de la adenosina (receptores y\/o transporte de adenosina) podr\u00eda estar alterada y relacionada con las manifestaciones del sln. la respuesta de los receptores de adenosina a2 y el efecto del exceso de hipoxantina sobre \u00e9stos no est\u00e1 alterada en la deficiencia de hprt. en los linfocitos hprt-deficientes (lln) est\u00e1n disminuidos el transporte de adenosina y los sitios de uni\u00f3n de nitrobenziltioinosina (nbti) por c\u00e9lula. Esta disminuci\u00f3n podr\u00eda ser debido a un menor transporte equilibrativo sensible a nbti (ent1). Un exceso de hipoxantina extracelular, caracter\u00edstica del sln, disminuye el transporte de adenosina total tanto en controles (lc) como en lln. En lc, la hipoxantina disminuye el transporte de adenosina concentrativo, ent1 y principalmente el equilibrativo insensible a nbti (ent2), que se acompa\u00f1a de una disminuci\u00f3n de los sitios de uni\u00f3n de nbti, pero no de la expresi\u00f3n de arnm de hent1 ni de hent2. En lln, esta disminuci\u00f3n se debe a un menor transporte por ent1 y principalmente por ent2, pero no a una disminuci\u00f3n del transporte concentrativo, ni de los sitios de uni\u00f3n de nbti. en las condiciones fisiopatol\u00f3gicas de la deficiencia de hprt, los lln transportan un 32% menos adenosina que los lc en sus condiciones fisiol\u00f3gicas normales. Los hallazgos de que esta disminuci\u00f3n del transporte de adenosina en los lln se debe a una disminuci\u00f3n del transporte por ent2 (principalmente por efecto de la hipoxantina) y ent1 (principalmente por efecto de la deficiencia de hprt) puede contribuir a un nuevo enfoque de f\u00e1rmacos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fisiopatolog\u00eda de las manifestaciones neurol\u00f3gicas del d\u00e9ficit de hipoxantina-guanina forroribosiltransferasa (hprt). implicaciones de las purinas como neuromoduladores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fisiopatolog\u00eda de las manifestaciones neurol\u00f3gicas del d\u00e9ficit de hipoxantina-guanina forroribosiltransferasa (hprt). implicaciones de las purinas como neuromoduladores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Prior De Castro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Garcia Puig<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Medina jimenez <\/li>\n<li>magdalena Ugarte p\u00e9rez (vocal)<\/li>\n<li>angel Sanchez rodriguez (vocal)<\/li>\n<li>mar\u00ed\u00a7al Pastor anglada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Prior De Castro La deficiencia de hprt es un grave trastorno del metabolismo de las purinas. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[52094,134781,7301,39034,15233,12645],"class_list":["post-61017","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-angel-sanchez-rodriguez","tag-carmen-prior-de-castro","tag-jose-maria-medina-jimenez","tag-juan-garcia-puig","tag-magdalena-ugarte-perez","tag-marial-pastor-anglada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61017","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=61017"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61017\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=61017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=61017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=61017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}