{"id":61122,"date":"2018-03-09T22:48:58","date_gmt":"2018-03-09T22:48:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-y-control-de-la-expresion-del-gen-hmg-coa-nuntasa-mitocondrial\/"},"modified":"2018-03-09T22:48:58","modified_gmt":"2018-03-09T22:48:58","slug":"significado-y-control-de-la-expresion-del-gen-hmg-coa-nuntasa-mitocondrial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/procesos-metabolicos\/significado-y-control-de-la-expresion-del-gen-hmg-coa-nuntasa-mitocondrial\/","title":{"rendered":"Significado y control de la expresion del gen hmg-coa nuntasa mitocondrial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ma Cristina Mayordomo Tella <\/strong><\/h2>\n<p>La s\u00edntesis de cuerpos cet\u00f3nicos es una v\u00eda clave en la respuesta metab\u00f3lica al ayuno. El enzima controlador de la v\u00eda, la hmgcs2, es un gen sometido a una estricta regulaci\u00f3n. Su expresi\u00f3n se regula, principalmente a nivel transcripcional, en situaci\u00f3n de ayuno, a trav\u00e9s de la presencia de \u00e1cidos grasos libres y del elevado ratio glucag\u00f3n\/insulina. Recientemente se ha constatado que su expresi\u00f3n tambi\u00e9n responde al estado proliferativo de la c\u00e9lula, pudi\u00e9ndose detectar su presencia en c\u00e9lulas diferenciadas o con una baja tasa de proliferaci\u00f3n. En este sentido, su expresi\u00f3n se apaga en diversos tipos de tumores, aunque de momento se desconocen las implicaciones de esta regulaci\u00f3n a la baja. Hoy en d\u00eda  existe un amplio conocimiento de las secuencias del promotor del gen de rata responsables de mediar estas repuestas, y de los factores de transcripci\u00f3n que se unen a ellas. En esta tesis, nuestros esfuerzos se han centrado en analizar la regulaci\u00f3n que sufren estos factores  de transcripci\u00f3n por prote\u00ednas coreguladoras, tanto en situaci\u00f3n de ayuno como durante los procesos de diferenciaci\u00f3n y proliferaci\u00f3n y en extender estos resultados al gen humano, y en determinar el papel que desempe\u00f1a el gen hmgcs2 en los procesos de proliferaci\u00f3n y  diferenciaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado y control de la expresion del gen hmg-coa nuntasa mitocondrial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado y control de la expresion del gen hmg-coa nuntasa mitocondrial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ma Cristina Mayordomo Tella <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/10\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Marrero Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Marta Giralt oms <\/li>\n<li>gabriel Gil g\u00f3mez (vocal)<\/li>\n<li>anna Messeguer navarro (vocal)<\/li>\n<li>ma Jos\u00e9 Barrero nu\u00f1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ma Cristina Mayordomo Tella La s\u00edntesis de cuerpos cet\u00f3nicos es una v\u00eda clave en la respuesta metab\u00f3lica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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