{"id":61284,"date":"2007-09-11T00:00:00","date_gmt":"2007-09-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-igf-i-y-cooperacion-de-lif-en-el-desarrollo-embrionario-del-pulmon\/"},"modified":"2007-09-11T00:00:00","modified_gmt":"2007-09-11T00:00:00","slug":"funcion-de-igf-i-y-cooperacion-de-lif-en-el-desarrollo-embrionario-del-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/funcion-de-igf-i-y-cooperacion-de-lif-en-el-desarrollo-embrionario-del-pulmon\/","title":{"rendered":"Funci\u00f3n de igf-i y cooperaci\u00f3n de lif en el desarrollo embrionario del pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nuria Moreno Barriuso <\/strong><\/h2>\n<p>Lif (leukaemia inhibitory factor) e igf-i (insulin-like growth factor i) son dos citoquinas multifuncionales miembros de dos familias diferentes que regulan funciones de supervivencia, proliferaci\u00f3n, diferenciaci\u00f3n y migraci\u00f3n en diversos tipos celulares y \u00f3rganos, inclu\u00eddo el pulm\u00f3n. como objetivos se plante\u00f3 estudiar la funci\u00f3n de igf-i y la colaboraci\u00f3n de lif durante la maduraci\u00f3n pulmonar as\u00ed como caracterizar tanto a nivel celular como molecular el fenotipo pulmonar de embriones de ratones mutantes para estos genes.  en este trabajo se demuestra que igf-i afecta diferencialmente al crecimiento del pulm\u00f3n en comparaci\u00f3n con el resto del embri\u00f3n ya que la carencia de este factor de crecimiento causa una hipoplasia pulmonar desproporcionada en relaci\u00f3n con el cuerpo del animal. Igf-i resulta ser esencial para el correcto desarrollo embrionario del pulm\u00f3n, regulando la proliferaci\u00f3n y la diferenciaci\u00f3n de los neumocitos de tipo ii a c\u00e9lulas de tipo i. Adem\u00e1s igf-i act\u00faa sobre la vascularizaci\u00f3n y el remodelado capilar, la deposici\u00f3n de los componentes de la matriz extracelular, y el desarrollo y diferenciaci\u00f3n de la musculatura lisa que tienen lugar durante la maduraci\u00f3n prenatal. Adem\u00e1s igf-i act\u00faa como modulador de la homeostasis de los procesos proinflamatorios y de defensa en el pulm\u00f3n en desarrollo. Los datos de expresi\u00f3n diferencial obtenidos mediante microarrays confirman funciones de igf-i en el desarrollo pulmonar anteriormente mencionadas y revelan otras nuevas como la adhesi\u00f3n celular, la eritropoyesis y el desarrollo del sistema nervioso, y ponen de manifiesto su implicaci\u00f3n en la v\u00eda de se\u00f1alizaci\u00f3n de mapk, wnt y calcio. Cabe mencionar que el rat\u00f3n knock-out para igf-i refleja el s\u00edndrome de distr\u00e9s respiratorio en humanos y se propone como modelo murino de esta enfermedad. Asimismo se muestra que los factores lif e igf-i cooperan funcionalmente durante el desarrollo del pulm\u00f3n prenatal, siendo el papel de lif desenmascarado con la ausencia de igf-i.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n de igf-i y cooperaci\u00f3n de lif en el desarrollo embrionario del pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n de igf-i y cooperaci\u00f3n de lif en el desarrollo embrionario del pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nuria Moreno Barriuso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Garcia Pichel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: faustino Mollinedo Garc\u00eda <\/li>\n<li>isabel Varela nieto (vocal)<\/li>\n<li>dionisio Miguel Mart\u00edn zanca (vocal)<\/li>\n<li>Mar\u00eda  del pilar Aroca tejedor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nuria Moreno Barriuso Lif (leukaemia inhibitory factor) e igf-i (insulin-like growth factor i) son dos citoquinas multifuncionales 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