{"id":61314,"date":"2018-03-09T22:49:10","date_gmt":"2018-03-09T22:49:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/candidate-gene-for-litter-size-and-its-components-progesterone-receptor-gene\/"},"modified":"2018-03-09T22:49:10","modified_gmt":"2018-03-09T22:49:10","slug":"candidate-gene-for-litter-size-and-its-components-progesterone-receptor-gene","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/seleccion-animal\/candidate-gene-for-litter-size-and-its-components-progesterone-receptor-gene\/","title":{"rendered":"Candidate gene for litter size and its components: progesterone receptor gene."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Peir\u00f3 Barber Rosa Mar\u00eda <\/strong><\/h2>\n<p>The general objective of this thesis is to study the effect of the rabbit progesterone receptor (pgr) gene on litter size and its components using a f2 population from a cross between two divergent lines selected for uterine capacity (uc) during 10 generations differing mainly in embryo survival.   in order to achieve better information to identify a physiological candidate gene, it was useful to determine the time of gestation in which differences in early embryo survival and development appeared. A total of 162 females from the high line, selected to increase uc, and 133 females from the low line, selected to decrease uc, were slaughtered at 25, 48 and 62 h of gestation. Both lines had similar ovulation rate and fertilization rate at the early stages of gestation. The high line had a higher embryo survival than the low line at 62 h of gestation (0.57 embryos), and also more embryonic stage of development at 48 and 62 h of gestation, showing a higher percentage of early morulae (10%) and higher percentage of compacted morulae (16%), respectively.  a total of 598 intact f2 females were obtained crossing 3 bucks of the high line with 13 unilaterally ovariectomized (ulo) does of the low line and crossing 3 bucks of the low line with 5 ulo does of the high line. The rabbit pgr gene was selected as candidate gene because progesterone is related to reproductive traits and also because knockout mice showed reproductive abnormalities. A 3702 bp sequence of the rabbit pgr gene was obtained from parental animals and five single nucleotide polymorphism (snp) were found; a snp was found in the promoter region, 2464g>a, three snps in the 5\u00c2\u00bfutr exon 1 and a silence snp in the exon 7. The snps found in the promoter region and in the 5\u00c2\u00bfutr were cosegregating in two haplotypes. A pcr-rflp method was developed for genotyping the 2464g>a snp in the promoter region.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Candidate gene for litter size and its components: progesterone receptor gene.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Candidate gene for litter size and its components: progesterone receptor gene. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Peir\u00f3 Barber Rosa Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Polit\u00e9cnica de Valencia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agust\u00edn Blasco Mateu<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Baselga izquierdo <\/li>\n<li>pierre Bidanel jean (vocal)<\/li>\n<li>chris Haley (vocal)<\/li>\n<li>Miguel angel Toro iba\u00f1ez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Peir\u00f3 Barber Rosa Mar\u00eda The general objective of this thesis is to study the effect of the 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