{"id":61373,"date":"2018-03-09T22:49:14","date_gmt":"2018-03-09T22:49:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-proteinas-de-adhesion-y-de-la-apoptosis-en-la-patologa%c2%ada-de-la-glnandula-salivarestudio-de-e-cadherina-cd44-laminina-bax-y-bcl-2\/"},"modified":"2018-03-09T22:49:14","modified_gmt":"2018-03-09T22:49:14","slug":"papel-de-las-proteinas-de-adhesion-y-de-la-apoptosis-en-la-patologa%c2%ada-de-la-glnandula-salivarestudio-de-e-cadherina-cd44-laminina-bax-y-bcl-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/papel-de-las-proteinas-de-adhesion-y-de-la-apoptosis-en-la-patologa%c2%ada-de-la-glnandula-salivarestudio-de-e-cadherina-cd44-laminina-bax-y-bcl-2\/","title":{"rendered":"Papel de las proteinas de adhesi\u00f3n y de la apoptosis en la patolog\u00eda de la gl\u00f1\u00e1ndula salivar:estudio de e-cadherina, cd44, laminina, bax y bcl-2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Saura Fillat <\/strong><\/h2>\n<p>El material humano objeto de estudio fue un total de 70 pacientes asistidos en el servicio de cirug\u00eda oral y maxilofacial del hospitaluniversitario miguel servet de zaragoza, por patolog\u00edas de gl\u00e1ndulas salivares mayores y menores, que requiri\u00f3 tratamientoquir\u00fargico con ex\u00e9resis parcial o total del \u00f3rgano afectado.El diagn\u00f3stico anatomopatol\u00f3gico permiti\u00f3 clasificar las muestras en dos grupos: 35 lesiones benignas, y 35 tumores malignos dediferentes estirpes y grados histol\u00f3gicos.En todas las muestras se investig\u00f3 &#8211; en el departamento de anatom\u00eda e histolog\u00eda de la universidad de zaragoza- tanto en el tejidopatol\u00f3gico benigno o maligno, como en el tejido sano adyacente a la lesi\u00f3n, y mediante t\u00e9cnicas inmuhistoqu\u00edmicas, el grado deexpresi\u00f3n de las prote\u00ednas de adhesi\u00f3n e-cadherina, cd44 y laminina, y de las prote\u00ednas reguladoras de la v\u00eda intr\u00ednseca omitocondrial de la apoptosis bax y bcl-2.De los resultados obtenidos y su discusi\u00f3n con los aportados por otros investigadores en las bases bibliogr\u00e1ficas, se alcanzaron lassiguientes conclusiones:1.- Existe una asociaci\u00f3n directa negativa entre la expresi\u00f3n de e-cadherina y el fenotipo histol\u00f3gico neopl\u00e1sico, con p\u00e9rdida de laexpresi\u00f3n proteica en los tumores m\u00e1s indiferenciados y en los epiteliales benignos m\u00e1s invasivos, en este sentido en los adenomaspleomorfos estar\u00eda relacionada con un mayor \u00edndice de recidivas tras resecciones parciales, y por tanto la opci\u00f3n terap\u00e9utica m\u00e1srecomendada ser\u00eda la extirpaci\u00f3n completa de la gl\u00e1ndula afectada.2.- Los tumores benignos tienen una expresi\u00f3n normal de cd44 y en el caso del adenoma pleomorfo una sobreexpresi\u00f3n, que puedeestar relacionada con la mayor elaboraci\u00f3n de matriz extracelular. En los tumores malignos de estirpe predominantemente epitelialno sc observa p\u00e9rdida de expresi\u00f3n o esta es debil, en cl resto de patolog\u00eda maligna la p\u00e9rdida de expresi\u00f3n puede condicionarinvasi\u00f3n del estroma y proliferaci\u00f3n celular.3.- La<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las proteinas de adhesi\u00f3n y de la apoptosis en la patolog\u00eda de la gl\u00f1\u00e1ndula salivar:estudio de e-cadherina, cd44, laminina, bax y bcl-2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las proteinas de adhesi\u00f3n y de la apoptosis en la patolog\u00eda de la gl\u00f1\u00e1ndula salivar:estudio de e-cadherina, cd44, laminina, bax y bcl-2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Saura Fillat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Azua Romeo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo Vera gil <\/li>\n<li>Manuel Chamorro pons (vocal)<\/li>\n<li>Jes\u00fas Esarte muniain (vocal)<\/li>\n<li>joaqu\u00ednq Garatea crelgo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Saura Fillat El material humano objeto de estudio fue un total de 70 pacientes asistidos en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[140,52,347,3178,13610],"tags":[28331,135571,102551,135572,135573,85070],"class_list":["post-61373","post","type-post","status-publish","format-standard","hentry","category-estomatologia-y-ortodoncia","category-histopatologia","category-oncologia-clinica","category-proteinas","category-zaragoza","tag-arturo-vera-gil","tag-esther-saura-fillat","tag-javier-azua-romeo","tag-jesus-esarte-muniain","tag-joaquinq-garatea-crelgo","tag-manuel-chamorro-pons"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=61373"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61373\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=61373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=61373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=61373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}