{"id":61382,"date":"2018-03-09T22:49:14","date_gmt":"2018-03-09T22:49:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hormona-tiroidea-sobre-la-expresion-del-gen-del-reeptor-de-cannabinoides-cb1-y-su-accion-en-cerebro-de-rata-durante-el-desarrollo\/"},"modified":"2018-03-09T22:49:14","modified_gmt":"2018-03-09T22:49:14","slug":"efecto-de-la-hormona-tiroidea-sobre-la-expresion-del-gen-del-reeptor-de-cannabinoides-cb1-y-su-accion-en-cerebro-de-rata-durante-el-desarrollo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hormona-tiroidea-sobre-la-expresion-del-gen-del-reeptor-de-cannabinoides-cb1-y-su-accion-en-cerebro-de-rata-durante-el-desarrollo\/","title":{"rendered":"Efecto de la hormona tiroidea sobre la expresi\u00f3n del gen del reeptor de cannabinoides cb1 y su acci\u00f3n en cerebro de rata durante el desarrollo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa De As\u00faa Corchado <\/strong><\/h2>\n<p>La disfunci\u00f3n tiroidea durante el desarrollo tiene, entre otras importantes consecuencias, alteraciones del sistema motor tanto en seres humanos como en animales de experimentaci\u00f3n. Aqu\u00ed demostramos que las ratas hipotiroideas cong\u00e9nitas muestran hiperactividad motora en la vida adulta. Este fenotipo se asocia con una disminuci\u00f3n de la expresi\u00f3n del gen del receptor cb1 en los ganglios basales. Consecuentemente, en estos animales se observa una disminuci\u00f3n del contenido de tr\u00e1nscritos del gen cb1 en el estriado y una disminuci\u00f3n de la uni\u00f3n del antagonista selectivo de cb1 [3h]-sr141716a al receptor en el estriado y el mesenc\u00e9falo. Concordante con esta bajada de expresi\u00f3n del gen cb1 en los animales hipotiroideos adultos, se observa tambi\u00e9n una disminuci\u00f3n de la respuesta a agonistas cannabinoides, medida mediante par\u00e1metros bioqu\u00edmicos (intercambio de gtp), gen\u00e9ticos (expresi\u00f3n de c-fos) y de comportamiento (actividad motora). Estas alteraciones son reversibles y por lo tanto el tratamiento con los niveles apropiados de hormonas tiroideas normaliza la expresi\u00f3n del gen del receptor cb1 y mejora notablemente la respuesta de comportamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hormona tiroidea sobre la expresi\u00f3n del gen del reeptor de cannabinoides cb1 y su acci\u00f3n en cerebro de rata durante el desarrollo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hormona tiroidea sobre la expresi\u00f3n del gen del reeptor de cannabinoides cb1 y su acci\u00f3n en cerebro de rata durante el desarrollo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa De As\u00faa Corchado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gregorio Angel Santos Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Guzm\u00e1n pastor <\/li>\n<li>\u00e1ngeles Garc\u00eda pascual (vocal)<\/li>\n<li>Fernando Rodriguez de fonseca (vocal)<\/li>\n<li>guillermo Estevil torrus (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa De As\u00faa Corchado La disfunci\u00f3n tiroidea durante el desarrollo tiene, entre otras importantes consecuencias, alteraciones del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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