{"id":61418,"date":"2018-03-09T22:49:18","date_gmt":"2018-03-09T22:49:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implication-of-tnf-superfamily-receptors-and-their-functional-antagonists-in-neuronal-apoptotic-cell-death\/"},"modified":"2018-03-09T22:49:18","modified_gmt":"2018-03-09T22:49:18","slug":"implication-of-tnf-superfamily-receptors-and-their-functional-antagonists-in-neuronal-apoptotic-cell-death","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/implication-of-tnf-superfamily-receptors-and-their-functional-antagonists-in-neuronal-apoptotic-cell-death\/","title":{"rendered":"Implication of tnf superfamily receptors and their functional antagonists in neuronal apoptotic cell death"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raffaella Gozzelino <\/strong><\/h2>\n<p>La apoptosis puede ser inducida a trav\u00e9s de numerosos est\u00edmulos, entre los cuales los receptores de muerte. Para promover la apoptosis, tnfa necesita la colaboraci\u00f3n de inhibidores de la trascripci\u00f3n del rna o de la s\u00edntesis proteica, como actd y chx. En este estudio demostramos como la citotoxicidad de tnfa en c\u00e9lulas pc12 y en neuronas corticales sensibilizadas con actd ocurre a trav\u00e9s de la activaci\u00f3n de la caspasa iniciadora 8, la generaci\u00f3n de tbid y la activaci\u00f3n de las pro-caspasas-9 y -3. Adem\u00e1s no se detectan diferencias de expresi\u00f3n, inducidas por tnfa\/actd, de prote\u00ednas involucradas en la formaci\u00f3n del complejo de se\u00f1alizaci\u00f3n de tnfa. El an\u00e1lisis de las principales prote\u00ednas antiapopt\u00f3ticas, como flip, iaps y miembros de la familia de bcl-2, demuestra que bcl-xl es la mol\u00e9cula end\u00f3gena capaz de regular la apoptosis promovida por tnfa, sin afectar la activaci\u00f3n de la v\u00eda del factor de trascripci\u00f3n nf-kb. La sobre-expresi\u00f3n de bcl-xl confiere resistencia a la muerte apopt\u00f3tica mediada por tnfa y actd, y su disminuci\u00f3n forzada es capaz de inducir muerte celular \u00fanicamente tratando con tnfa por activaci\u00f3n de jnk. Para confirmar la relevancia de bcl-xl en la se\u00f1al promovida por tnfa, la represi\u00f3n de prote\u00ednas anti-apopt\u00f3ticas como bcl-2, bcl-xl, bcl-w y mcl-1 ha sido evaluada en el modelo de c\u00e9lulas hela, donde estas se expresan fisiol\u00f3gicamente al contrario que en las c\u00e9lulas pc12, demostrando que bcl-xl es la prote\u00edna anti-apopt\u00f3tica m\u00e1s importante en la protecci\u00f3n de la muerte inducida por tnfa.  por otra parte, la apoptosis mediada por tnfa puede ser promovida por la acumulaci\u00f3n de elevados niveles del grupo hemo libre, una mol\u00e9cula imprescindible en numerosas funciones biol\u00f3gicas. El grupo hemo sensibiliza las c\u00e9lulas hepa a la acci\u00f3n citot\u00f3xica de la citoquina tnfa a trav\u00e9s de la inducci\u00f3n de estr\u00e9s oxidativo, cuyo da\u00f1o resulta en la activaci\u00f3n de la v\u00eda de jnk y de pro-caspasa-3. La producci\u00f3n de ro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implication of tnf superfamily receptors and their functional antagonists in neuronal apoptotic cell death<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implication of tnf superfamily receptors and their functional antagonists in neuronal apoptotic cell death <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raffaella Gozzelino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Xavier Comella Carnice<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Rodriguez alvarez <\/li>\n<li>ram\u00f3n Trullas oliva (vocal)<\/li>\n<li> Che perreira soares Miguel (vocal)<\/li>\n<li>patricia Boya tremoleda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raffaella Gozzelino La apoptosis puede ser inducida a trav\u00e9s de numerosos est\u00edmulos, entre los cuales los receptores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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