{"id":6146,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estudio-de-la-respuesta-de-anticuerpos-anti-ribonucleoproteina-ro-ssa-la-ssb-sm-u1rnp-p0-p1-y-p2-y-antilaminina-en-pacientes-con-lupus-eritematoso-sistemico-y-en-infestaciones-por-parasitos\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estudio-de-la-respuesta-de-anticuerpos-anti-ribonucleoproteina-ro-ssa-la-ssb-sm-u1rnp-p0-p1-y-p2-y-antilaminina-en-pacientes-con-lupus-eritematoso-sistemico-y-en-infestaciones-por-parasitos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-respuesta-de-anticuerpos-anti-ribonucleoproteina-ro-ssa-la-ssb-sm-u1rnp-p0-p1-y-p2-y-antilaminina-en-pacientes-con-lupus-eritematoso-sistemico-y-en-infestaciones-por-parasitos\/","title":{"rendered":"Estudio de la respuesta de anticuerpos anti-ribonucleoproteina (ro\/ssa, la\/ssb, sm, u1rnp, p0, p1 y p2) y antilaminina en pacientes con lupus eritematoso sistemico y en infestaciones por parasitos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Lerma Jos\u00e9 Gerardo <\/strong><\/h2>\n<p>El trabajo desarrollado se fundamenta en el estudio comparativo de la respuesta de anticuerpos anti-ribonucleoproteina (rnp) y anti-laminina (lmn) en pacientes con enfermedades autoinmunes como el lupus eritematoso sistemico (les) y en infestaciones por parasitos. El estudio de la reactividad de sueros de pacientes parasitados por inmunofluorescencia indico la existencia de anticuerpos dirigidos a componentes nucleares citoplasmicos, y de matriz extracelular en la mayoria de ellos. Aunque por elisa un alto porcentaje poseia anticuerpos anti-rnp, estos resultados son falsamente positivos basandose en estudios de western blot e inmunoprecipitacion de arn. Por otro lado, el estudio comparativo de la actividad anti-imn detectada en les y en filariasis ha permitido demostrar diferencias en el reconocimiento de esta glicoproteina por ambos grupos de pacientes. Los resultados obtenidos apoyan el concepto de especificidad entre la presencia de anticuerpos anti-rnp y enfermedades autoinmunes, indicando que una activacion policlonal indiscriminada no origina el reconocimiento de estos autoantigenos muy conservados.  por otro lado, las diferencias de reactividad anti-imn observadas apoyan la hipotesis de que los autoanticuerpos producidos por inmunizacion con autoantigenos o moleculas similares presentes en parasitos, poseen especificidades distintas a los originados espontaneamente en enfermedades autoinmunes como el les.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta de anticuerpos anti-ribonucleoproteina (ro\/ssa, la\/ssb, sm, u1rnp, p0, p1 y p2) y antilaminina en pacientes con lupus eritematoso sistemico y en infestaciones por parasitos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta de anticuerpos anti-ribonucleoproteina (ro\/ssa, la\/ssb, sm, u1rnp, p0, p1 y p2) y antilaminina en pacientes con lupus eritematoso sistemico y en infestaciones por parasitos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Lerma Jos\u00e9 Gerardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julia Sequi Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Agustin Gregorio Zapata Gonzalez <\/li>\n<li>Garbi\u00f1e Roy Ari\u00f1o (vocal)<\/li>\n<li>Antonio Arnaiz Villena (vocal)<\/li>\n<li>Pilar Palomino Diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Lerma Jos\u00e9 Gerardo El trabajo desarrollado se fundamenta en el estudio comparativo de la respuesta de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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