{"id":61468,"date":"2018-03-09T22:49:21","date_gmt":"2018-03-09T22:49:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-oncogenico-del-carcinoma-adenoide-quistico-de-glandulas-salivales\/"},"modified":"2018-03-09T22:49:21","modified_gmt":"2018-03-09T22:49:21","slug":"perfil-oncogenico-del-carcinoma-adenoide-quistico-de-glandulas-salivales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/perfil-oncogenico-del-carcinoma-adenoide-quistico-de-glandulas-salivales\/","title":{"rendered":"Perfil oncogenico del carcinoma adenoide quistico de glandulas salivales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guadalupe Sequeiros Santiago <\/strong><\/h2>\n<p>El carcinoma adenoide qu\u00edstico (caq) de gl\u00e1ndulas salivales es un tipo de tumor para el que los mecanismos moleculares subyacentes a su desarrollo permanecen a\u00fan por esclarecer. Debido a su baja incidencia, el estudio de caq se ve dificultado por la imposibilidad de acumular un n\u00famero de casos suficientemente grande como para que los an\u00e1lisis estad\u00edsticos sean concluyentes. En este trabajo hemos reunido tantos casos como ha sido posible, recurriendo tanto al servicio de orl como al de m\u00e1xilofacial. En la presente tesis se describe el patr\u00f3n de amplificaciones oncog\u00e9nicas afectando a genes cruciales en la tumorig\u00e9nesis humana, como son erbb1, ccnd1, pik3ca, c-myc, c-kit y mdm2. Asimismo, se estudi\u00f3 el nivel de expresi\u00f3n proteica de egfr, ciclina d1 y c-kit. Nuestros resultados indican el valor de la amplificaci\u00f3n de erbb1 (la m\u00e1s frecuente, entre las dianas estudiadas) en la predicci\u00f3n de aparici\u00f3n de met\u00e1stasis. Los tumores que acumulaban amplificaci\u00f3n de dos o m\u00e1s oncogenes tend\u00edan a presentar invasi\u00f3n perineural con mayor frecuencia. La expresi\u00f3n de egfr estaba ausente en todos los tumores. La expresi\u00f3n de ciclina d1 era exclusiva del componente epitelial de los caqs y era m\u00e1s intensa en los casos con mayor proporci\u00f3n de componente epitelial, lo cual podr\u00eda sugerir un papel de ciclina d1 en la proliferaci\u00f3n de estas c\u00e9lulas. Mientras que la amplificaci\u00f3n g\u00e9nica podr\u00eda justificar buena parte de la sobreexpresi\u00f3n de ciclina d1, no ocurr\u00eda lo mismo para c-kit, que presentaba diversos niveles de expresi\u00f3n y tan s\u00f3lo un caso portaba amplificaci\u00f3n g\u00e9nica. El patr\u00f3n oncog\u00e9nico que se repet\u00eda con mayor frecuencia implicaba la amplificaci\u00f3n de erbb1, ccnd1 y pik3ca, presentando los pacientes con los tumores portadores una supervivencia que tend\u00eda a ser m\u00e1s corta que la de los pacientes libres de tal alteraci\u00f3n. A pesar que esta \u00faltima observaci\u00f3n no alcanz\u00f3 significaci\u00f3n estad\u00edstica, s\u00ed que marca la direcci\u00f3n de posibles e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perfil oncogenico del carcinoma adenoide quistico de glandulas salivales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perfil oncogenico del carcinoma adenoide quistico de glandulas salivales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guadalupe Sequeiros Santiago <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Victoria Gonzalez Meana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Suarez nieto <\/li>\n<li>Jos\u00e9 Martinez vidal (vocal)<\/li>\n<li>david alonso Hardisson hernaez (vocal)<\/li>\n<li>xavier Leon vintro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guadalupe Sequeiros Santiago El carcinoma adenoide qu\u00edstico (caq) de gl\u00e1ndulas salivales es un tipo de tumor para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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