{"id":61503,"date":"2018-03-09T22:49:21","date_gmt":"2018-03-09T22:49:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/osteonecrosis-de-los-maxilares-en-relacion-con-la-quimioterapia-antineoplasica\/"},"modified":"2018-03-09T22:49:21","modified_gmt":"2018-03-09T22:49:21","slug":"osteonecrosis-de-los-maxilares-en-relacion-con-la-quimioterapia-antineoplasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estomatologia-y-ortodoncia\/osteonecrosis-de-los-maxilares-en-relacion-con-la-quimioterapia-antineoplasica\/","title":{"rendered":"Osteonecrosis de los maxilares en relaci\u00f3n con la quimioterapia antineopl\u00e1sica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Hern\u00e1ndez Baz\u00e1n Sergio Sergio <\/strong><\/h2>\n<p>Introducci\u00f3n y revisi\u00f3n bibliogr\u00e1ficala osteorradionecrosis mandibular, es una importante complicaci\u00f3n que puede manifestarse en pacientes tratados con radioterapia de cabeza y cuello. Afecta sobre todo al cuerpo mandibular y en el 50% de los casos, el origen es una extracci\u00f3n dentaria, manifest\u00e1ndose un \u00e1rea de osteomielitis con necrosis \u00f3sea, siendo la misma dif\u00edcilmente tratable. Del mismo modo, existen otros factores que condicionan la aparici\u00f3n de la osteonecrosis como son: las infecciones f\u00fangicas, factores traum\u00e1ticos, el herpes zoster y la sialometaplasia  necrotizante, as\u00ed como algunos medicamentos. \u00faltimamente, se est\u00e1 relacionando incluso con el tratamiento de quimioterapia antineopl\u00e1sica y en particular, con el uso de los bisfosfonatos.  Estos medicamentos, son com\u00fanmente utilizados en el tratamiento de los pacientes con tumores malignos, que presentan una hipercalcemia o met\u00e1stasis \u00f3seas puesto que inhiben la actividad osteocl\u00e1stica y originan un efecto antiangiog\u00e9nico, lo que permite tambi\u00e9n el uso de este medicamento en el tratamiento de enfermedades inflamatorias como son la enfermedad de paget, o la osteoporosis. los bisfosfonatos m\u00e1s com\u00fanmente utilizados son el pamidronato s\u00f3dico, y el zoledronato s\u00f3dico, que act\u00faan inhibiendo la resorci\u00f3n \u00f3sea y sus efectos se sustentan en la inhibici\u00f3n de la actividad osteocl\u00e1stica sin embargo de ambos se desconoce su mecanismo espec\u00edfico de actuaci\u00f3n en 2003, el dr. Robert marx 8, determina la aparici\u00f3n de 36 casos de exposici\u00f3n \u00f3sea maxilar, mandibular o de ambos maxilares, que no respond\u00edan a ning\u00fan tratamiento m\u00e9dico o quir\u00fargico. Todos estos pacientes estaban recibiendo tratamiento con pamidronato (aredia; novartis pharmaceuticals) o zoledronato (zometa; novartis pharmaceuticals). Del mismo modo determin\u00f3 que con un m\u00ednimo trauma era suficiente para la aparici\u00f3n de estas lesiones osteonecr\u00f3ticas, con aparici\u00f3n de infecciones y una cascada de complicaciones m\u00e9d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Osteonecrosis de los maxilares en relaci\u00f3n con la quimioterapia antineopl\u00e1sica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Osteonecrosis de los maxilares en relaci\u00f3n con la quimioterapia antineopl\u00e1sica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Hern\u00e1ndez Baz\u00e1n Sergio Sergio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Vicente Bagan Sebastian<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Basterra alegria <\/li>\n<li>Jos\u00e9 L\u00f3pez l\u00f3pez (vocal)<\/li>\n<li>alejandro Ceballos (vocal)<\/li>\n<li>eduardo Chimenos k\u00ed\u00bcstner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hern\u00e1ndez Baz\u00e1n Sergio Sergio Introducci\u00f3n y revisi\u00f3n bibliogr\u00e1ficala osteorradionecrosis mandibular, es una importante complicaci\u00f3n que puede manifestarse [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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