{"id":61527,"date":"2018-03-09T22:49:25","date_gmt":"2018-03-09T22:49:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-transcritos-alternativos-del-gen-trka-y-analisis-de-metilacion-de-su-promotor-en-neuroblastonas\/"},"modified":"2018-03-09T22:49:25","modified_gmt":"2018-03-09T22:49:25","slug":"estudio-de-transcritos-alternativos-del-gen-trka-y-analisis-de-metilacion-de-su-promotor-en-neuroblastonas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/estudio-de-transcritos-alternativos-del-gen-trka-y-analisis-de-metilacion-de-su-promotor-en-neuroblastonas\/","title":{"rendered":"Estudio de transcritos alternativos del gen trka y an\u00e1lisis de metilaci\u00f3n de su promotor en neuroblastonas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Andres Mart\u00edn <\/strong><\/h2>\n<p>Trka es un receptor tirosina quinasa perteneciente a la familia de receptores trk, cuyos ligandos son las neurotrofinas de la familia del factor de crecimiento nervioso (ngf). Las neurotrofinas regulan supervivencia, crecimiento, diferenciaci\u00f3n y apoptosis y adem\u00e1s participan en actividades neuronales especializadas. Trka es el receptor del ngf y tambi\u00e9n puede unir, aunque con baja afinidad, las neurotrofinas 3 y 4. El locus trka codifica diversas variantes de la prote\u00edna como consecuencia del uso alternativo de exones. Una de estas formas tiene m\u00e1s afinidad por nt3. En este trabajo hemos identificado nuevos transcritos de trka generados por procesamiento alternativo de diversos exones del gen. Dos de estos transcritos, trka\u00c2\u00bfe4 y trka\u00c2\u00bfe2,3 codifican variantes que carecen de algunos de los dominios del dominio extracelular del receptor, las cuales se procesan y responden a los ligandos de trka de forma diferente a la del receptor wt. Adem\u00e1s, a diferencia de trkawt, trka\u00c2\u00bfe2,3 se acumula alrededor del nucleo, en el ret\u00edculo endopl\u00e1smico y\/o en la envuelta nuclear.   por otra parte, se hab\u00edan identificado formas mutantes de p\u00e9rdida de funci\u00f3n de trka en pacientes afectados de insensibilidad cong\u00e9nita al dolor con anhidrosis (cipa). Hemos identificado una nueva mutaci\u00f3n de trka asociada a cipa en una paciente espa\u00f1ola, que da lugar al cambio de leucina a prolina en el amino\u00e1cido 711 (trkal711p). Trkal711p no posee actividad tirosina quinasa, presenta un defecto de procesamiento hacia la forma m\u00e1s madura de la prote\u00edna y su localizaci\u00f3n en la membrana plasm\u00e1tica est\u00e1 disminu\u00edda.   por \u00faltimo, la v\u00eda ngf\/trka es fundamental para la diferenciaci\u00f3n de determinadas poblaciones neuronales durante el desarrollo y su inactivaci\u00f3n durante este proceso podr\u00eda contribuir a la formaci\u00f3n de tumores derivados de progenitores neuronales por falta de una se\u00f1al diferenciadora. Como un posible mecanismo de la p\u00e9rdida de expresi\u00f3n del gen en tumores de origen neuronal, hemos analizado la metilaci\u00f3n de la isla cpg de trka en 23 neuroblastomas humanos. En estos tumores, no existe correlaci\u00f3n entre el nivel de expresi\u00f3n y el grado de metilaci\u00f3n de trka.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de transcritos alternativos del gen trka y an\u00e1lisis de metilaci\u00f3n de su promotor en neuroblastonas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de transcritos alternativos del gen trka y an\u00e1lisis de metilaci\u00f3n de su promotor en neuroblastonas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Andres Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dionisio Miguel Mart\u00edn Zanca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ignacio vicente Sandoval rodr\u00edguez <\/li>\n<li>Jorge Martin perez (vocal)<\/li>\n<li>joan xavier Comella carnice (vocal)<\/li>\n<li>Juan  Carlos Ar\u00e9valo mart\u00edn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Andres Mart\u00edn Trka es un receptor tirosina quinasa perteneciente a la familia de receptores trk, cuyos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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